| Formal nucleophilic substitution of bromocyclopropanes with amides en route to conformationally constrained β-amino acid derivatives. | |
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MedLine Citation:
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PMID: 20726591 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A chemo- and diastereoselective protocol for the formal nucleophilic substitution of 2-bromocyclopropylcarboxamides with secondary amides is described. This method allows for convergent and highly selective synthesis of trans-β-aminocyclopropane carboxylic acid derivatives. |
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Authors:
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Anthony R Prosser; Joseph E Banning; Marina Rubina; Michael Rubin |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Organic letters Volume: 12 ISSN: 1523-7052 ISO Abbreviation: Org. Lett. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-10 Completed Date: 2010-12-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100890393 Medline TA: Org Lett Country: United States |
Other Details:
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Languages: eng Pagination: 3968-71 Citation Subset: IM |
Affiliation:
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Department of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, Kansas 66045-75832, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amides
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chemistry* Amino Acids / chemistry* Bromine Compounds / chemistry* Cyclopropanes / chemistry* Models, Molecular Molecular Conformation |
| Chemical | |
Reg. No./Substance:
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0/Amides; 0/Amino Acids; 0/Bromine Compounds; 0/Cyclopropanes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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