Document Detail


Foreign fetal cells persist in the maternal circulation.
MedLine Citation:
PMID:  18384774     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine whether allogenic fetal cells resulting from donor egg pregnancies persist in maternal circulation. DESIGN: Nested polymerase chain reaction (PCR) amplification of the DYS14 sequence, a region of the Y chromosome, from DNA purified from peripheral blood cells. SETTING: Academic medical center. PATIENT(S): Healthy 18-60-year-old women who have had donor egg pregnancies resulting in a male offspring (n = 11) or, as a control, female offspring (n = 8), at least 1 year previously and without any other source for male cells in their peripheral blood or a healthy male. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Detection of DYS14 sequence by nested PCR. RESULT(S): DYS14 was detected in 5/11 (45%) of women who had donor egg pregnancies resulting in a male offspring, but in 0/8 (0) of women who had donor egg pregnancies resulting in a female offspring. The longest interval between delivery of a male offspring and detection of the DYS14 gene was 9 years. CONCLUSION(S): Unmatched, allogenic fetal cells from donor egg pregnancies are able to persist in the circulation of healthy women for at least 9 years after delivery. This implies a novel mechanism by which immunologic detection is avoided by these cells and may impact on how they may be used for regenerative and transplant medicine.
Authors:
Zev Williams; Dimity Zepf; Janina Longtine; Raymond Anchan; Betsy Broadman; Stacey A Missmer; Mark D Hornstein
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-04-01
Journal Detail:
Title:  Fertility and sterility     Volume:  91     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-01     Completed Date:  2009-07-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2593-5     Citation Subset:  IM    
Affiliation:
Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. zwilliams2@partners.org
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Chimerism
Chromosomes, Human, Y / genetics*
DNA / blood*,  genetics
Female
Fertilization in Vitro*
Humans
Male
Middle Aged
Polymerase Chain Reaction
Pregnancy
Young Adult
Chemical
Reg. No./Substance:
9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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