Document Detail

Foreign body reaction to biomaterials.
MedLine Citation:
PMID:  18162407     Owner:  NLM     Status:  MEDLINE    
The foreign body reaction composed of macrophages and foreign body giant cells is the end-stage response of the inflammatory and wound healing responses following implantation of a medical device, prosthesis, or biomaterial. A brief, focused overview of events leading to the foreign body reaction is presented. The major focus of this review is on factors that modulate the interaction of macrophages and foreign body giant cells on synthetic surfaces where the chemical, physical, and morphological characteristics of the synthetic surface are considered to play a role in modulating cellular events. These events in the foreign body reaction include protein adsorption, monocyte/macrophage adhesion, macrophage fusion to form foreign body giant cells, consequences of the foreign body response on biomaterials, and cross-talk between macrophages/foreign body giant cells and inflammatory/wound healing cells. Biomaterial surface properties play an important role in modulating the foreign body reaction in the first two to four weeks following implantation of a medical device, even though the foreign body reaction at the tissue/material interface is present for the in vivo lifetime of the medical device. An understanding of the foreign body reaction is important as the foreign body reaction may impact the biocompatibility (safety) of the medical device, prosthesis, or implanted biomaterial and may significantly impact short- and long-term tissue responses with tissue-engineered constructs containing proteins, cells, and other biological components for use in tissue engineering and regenerative medicine. Our perspective has been on the inflammatory and wound healing response to implanted materials, devices, and tissue-engineered constructs. The incorporation of biological components of allogeneic or xenogeneic origin as well as stem cells into tissue-engineered or regenerative approaches opens up a myriad of other challenges. An in depth understanding of how the immune system interacts with these cells and how biomaterials or tissue-engineered constructs influence these interactions may prove pivotal to the safety, biocompatibility, and function of the device or system under consideration.
James M Anderson; Analiz Rodriguez; David T Chang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2007-12-26
Journal Detail:
Title:  Seminars in immunology     Volume:  20     ISSN:  1044-5323     ISO Abbreviation:  Semin. Immunol.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-17     Completed Date:  2008-07-03     Revised Date:  2014-11-09    
Medline Journal Info:
Nlm Unique ID:  9009458     Medline TA:  Semin Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  86-100     Citation Subset:  IM    
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MeSH Terms
Biocompatible Materials* / adverse effects
Cell Adhesion / immunology
Cell Communication / immunology
Cell Differentiation / immunology
Cytokines / immunology
Foreign-Body Reaction / immunology*,  pathology,  physiopathology
Giant Cells, Foreign-Body / immunology,  pathology
Macrophages / immunology,  pathology
Regenerative Medicine / trends
Tissue Engineering
Grant Support
Reg. No./Substance:
0/Biocompatible Materials; 0/Cytokines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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