Document Detail

Forecasting of life threatening arrhythmias using the compression entropy of heart rate.
MedLine Citation:
PMID:  15136870     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Ventricular tachycardia (VT) provoking sudden cardiac death (SCD) are a major cause of mortality in the developed countries. The most efficient therapy for SCD prevention are implantable cardioverter defibrillators (ICD). In this study heart rate variability (HRV) measures were analyzed for short-term forecasting of VT in order to improve VT sensing and to enable a patient warning of forth-coming shocks. METHODS: The last 1000 normal beat-to-beat intervals before 50 VT episodes stored by the ICD were analyzed and compared to individually acquired control time series (CON). HRV analysis was performed with standard parameters of time and frequency domain as suggested by the HRV Task Force and furthermore with a newly developed and optimized nonlinear parameter that assesses the compression entropy of heart rate (Hc). RESULTS: Except of meanNN (p = 0.02) we found no significant differences in standard HRV parameters. In contrast, Hc revealed highly significant (p = 0.007) alterations in VT compared with CON suggesting a decreased complexity before the onset of VT. CONCLUSION: Compression entropy might be a suitable parameter for short-term forecasting of life-threatening tachycardia in ICD.
M Baumert; V Baier; J Haueisen; N Wessel; U Meyerfeldt; A Schirdewan; A Voss
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Methods of information in medicine     Volume:  43     ISSN:  0026-1270     ISO Abbreviation:  Methods Inf Med     Publication Date:  2004  
Date Detail:
Created Date:  2004-05-11     Completed Date:  2004-07-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0210453     Medline TA:  Methods Inf Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  202-6     Citation Subset:  IM    
University of Applied Sciences Jena, Department of Medical Engineering, Carl-Zeiss-Promenade 2, 07745 Jena, Germany.
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MeSH Terms
Arrhythmias, Cardiac / diagnosis*,  physiopathology
Defibrillators, Implantable
Heart Rate*
Nonlinear Dynamics

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