Document Detail

Forebrain ischemia in the rat. Relation between duration of ischemia, use of adjunctive ganglionic blockade and long-term recovery.
MedLine Citation:
PMID:  2876536     Owner:  NLM     Status:  MEDLINE    
The relation between duration of ischemia, use of adjunctive ganglionic blockade and long-term recovery was studied in a rat model giving reversible subtotal forebrain ischemia. Ischemia was induced by bilateral carotid artery clamping and controlled hemorrhage to a mean arterial pressure of 50 mm Hg in animals artificially ventilated under 70% N2O. After variable lengths of time, the clamps were removed and the drawn blood was reinfused. In some animals, the ganglion blocker Arfonad was given (group A+) on induction of ischemia to facilitate hypotension. There was a strict dose-response relationship between duration of ischemia and mortality. Mortality was higher among animals not given Arfonad (group A-; 37% after 10 min of ischemia and 100% after 13 min) than in group A+ (about 20% after 12-13 min of ischemia, 50% after 15 min and 80% after 19 min). In group A+ more than half of the animals died later than 24 h after ischemia. All of them were hyperexcitable and 12% died during witnessed epileptic fits. Group A- animals regularly died within the first 24 h, with no indication of central nervous system involvement. Less blood had to be drawn to attain hypotension (mean arterial pressure 50 mm Hg) in group A+ (1.5 +/- 0.3 ml/100 g b.w.) than in group A- (2.5 +/- 0.2 ml/100 g b.w.). Group A+ also had less "washout" acidosis 5 min after reinfusion of the shed blood than group A- (15 min of ischemia: pH 7.24 +/- 0.07 v 6.96 +/- 0.06).(ABSTRACT TRUNCATED AT 250 WORDS)
B Grøgaard; B Gerdin; K E Arfors
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  17     ISSN:  0039-2499     ISO Abbreviation:  Stroke     Publication Date:    1986 Sep-Oct
Date Detail:
Created Date:  1986-11-19     Completed Date:  1986-11-19     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1010-5     Citation Subset:  IM    
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MeSH Terms
Blood Pressure
Disease Models, Animal*
Dose-Response Relationship, Drug
Ganglionic Blockers*
Ischemic Attack, Transient / chemically induced,  pathology*
Rats, Inbred Strains
Time Factors
Reg. No./Substance:
0/Ganglionic Blockers; 68-91-7/trimethaphan camsylate; 7187-66-8/Trimethaphan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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