Document Detail


Forebrain cell proliferation, behavior, and physiology of zebrafish, Danio rerio, kept in enriched or barren environments.
MedLine Citation:
PMID:  20385156     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Comparative studies on neural plasticity in non-mammalian vertebrates are increasingly promoted as an important complement to mammalian models. In teleost fishes the number of brain cells increases with age, body weight, and body length throughout life. Neurogenesis persists to a large degree, and both neuron replacement and net brain growth occur during adulthood. Whether environmental factors affect brain cell proliferation has however been scarcely investigated in this animal group. In the current study adult male zebrafish were kept in social isolation in different environments (enriched vs. barren) for one week. Telencephalic cell proliferation was investigated by proliferating cell nuclear antigen (PCNA) immunohistochemistry. Higher numbers of PCNA positive nuclei and significantly increased inter-individual variability was observed in fish kept in aquaria enriched with artificial plants and gravel. Zebrafish rapidly regained feed intake after transfer to social isolation. Whole-body cortisol levels were also generally low in isolated fish, although slightly elevated in fish from enriched environments. In summary, this study demonstrates that environmental alterations can rapidly alter cell cycle dynamics in the zebrafish brain. Furthermore, the results support the idea that mild short-term stressors and concomitant small increases in corticosteroid exposure stimulate brain cell proliferation.
Authors:
Kristine von Krogh; Christina Sørensen; Göran E Nilsson; Øyvind Øverli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-04-10
Journal Detail:
Title:  Physiology & behavior     Volume:  101     ISSN:  1873-507X     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-08     Completed Date:  2010-11-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  32-9     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Affiliation:
Department of Production Animal Sciences, Norwegian School of Veterinary Science, P.O. Box 8146 Dep., N-0033 Oslo, Norway. oyvind.overli@umb.no
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MeSH Terms
Descriptor/Qualifier:
Animals
Anthracenes
Behavior, Animal / physiology*
Cell Proliferation
Environment
Hydrocortisone / physiology
Male
Neurogenesis / physiology*
Neuronal Plasticity / physiology*
Proliferating Cell Nuclear Antigen / metabolism*
Prosencephalon / cytology,  growth & development*
Social Isolation
Statistics, Nonparametric
Zebrafish
Zebrafish Proteins / metabolism*
Chemical
Reg. No./Substance:
0/AnOV compound; 0/Anthracenes; 0/Proliferating Cell Nuclear Antigen; 0/Zebrafish Proteins; 50-23-7/Hydrocortisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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