Document Detail


A forebrain-retrorubral pathway involved in male sex behavior is GABAergic and activated with mating in gerbils.
MedLine Citation:
PMID:  21118711     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ventral bed nuclei of the stria terminalis (BST) and medial preoptic nucleus (MPN) of gerbils contain cells that regulate male sex behavior via a largely uncrossed pathway to the retrorubral field (RRF). Our goal was to learn more about cells at the pathway source and target. To determine if the pathway uses GABA as its transmitter, we used immunocytochemistry (ICC) to study glutamic acid decarboxlyase(67) (GAD(67)) colocalization with fluoro-gold (FG) in the ventral BST and MPN after applying FG to the RRF. To determine if the pathway is activated with mating, we studied FG-Fos colocalization in the ventral BST of recently mated males. The ventral BST expresses Fos with mating and is the major pathway source. To determine to what extent other GABAergic cells in the ventral BST are activated with mating, we studied Fos colocalization with GAD(67) mRNA visualized by in situ hybridization (ISH). We also looked for GAD(67) mRNA in RRF cells. Almost all ventral BST and MPNm cells projecting to the RRF (95-97%) and most ventral BST cells activated with mating (89%), were GABAergic. GABAergic cells were also seen in the RRF. RRF-projecting cells represented 37% of ventral BST cells activated with mating. Their activation may reflect arousal and anticipation of sexual reward. Among ventral BST cells that project to the RRF, 14% were activated with mating, consistent with how much of this pathway is needed for mating. The activated GABAergic cells that do not project to the RRF may release GABA locally and inhibit ejaculation.
Authors:
D A Simmons; N W Hoffman; P Yahr
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-11-29
Journal Detail:
Title:  Neuroscience     Volume:  175     ISSN:  1873-7544     ISO Abbreviation:  Neuroscience     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-26     Completed Date:  2012-06-01     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  United States    
Other Details:
Languages:  eng     Pagination:  162-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 IBRO. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Department of Neurobiology and Behavior, University of California, Irvine, CA 92697-4550, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Enzyme Activation / physiology
Female
Gerbillinae
Glutamate Decarboxylase / metabolism,  physiology
Male
Neural Pathways / cytology,  enzymology,  physiology
Preoptic Area / cytology,  enzymology,  physiology
Prosencephalon / cytology,  enzymology,  physiology*
Septal Nuclei / cytology,  enzymology,  physiology
Sex Characteristics*
Sexual Behavior, Animal / physiology*
Tegmentum Mesencephali / cytology,  enzymology,  physiology*
gamma-Aminobutyric Acid / physiology*
Grant Support
ID/Acronym/Agency:
MH-26481/MH/NIMH NIH HHS; R01 MH026481-24/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
56-12-2/gamma-Aminobutyric Acid; EC 4.1.1.15/Glutamate Decarboxylase; EC 4.1.1.15/glutamate decarboxylase 1
Comments/Corrections

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