| Forced swimming in rats: hypothermia, immobility and the effects of imipramine. | |
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MedLine Citation:
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PMID: 258612 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rats when forced to swim in a restricted space not only became immobile but showed marked hypothermia. The hypothermia was greater than that observed after reserpine or Ro 4-1284 and was not antagonized by imipramine at doses which significantly reduced immobility. Hypothermia induced by forced swimming can therefore be dissociated from the immobility occurring in these conditions and also from drug-induced hypothermia. |
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Authors:
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R D Porsolt; M Deniel; M Jalfre |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of pharmacology Volume: 57 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1979 Aug |
Date Detail:
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Created Date: 1979-12-27 Completed Date: 1979-12-27 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 431-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-
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pharmacology Animals Body Temperature / drug effects* Imipramine / pharmacology* Male Motor Activity / drug effects, physiology* Rats Reserpine / pharmacology Swimming* Time Factors |
| Chemical | |
Reg. No./Substance:
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303-75-3/2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-; 50-49-7/Imipramine; 50-55-5/Reserpine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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