Document Detail

Forced oscillation technique in the detection of smoking-induced respiratory alterations: diagnostic accuracy and comparison with spirometry.
MedLine Citation:
PMID:  21340218     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Detection of smoking effects is of utmost importance in the prevention of cigarette-induced chronic airway obstruction. The forced oscillation technique offers a simple and detailed approach to investigate the mechanical properties of the respiratory system. However, there have been no data concerning the use of the forced oscillation technique to evaluate respiratory mechanics in groups with different degrees of tobacco consumption.
OBJECTIVES: (1) to evaluate the ability of the forced oscillation technique to detect smoking-induced respiratory alterations, with special emphasis on early alterations; and (2) to compare the diagnostic accuracy of the forced oscillation technique and spirometric parameters.
METHODS: One hundred and seventy subjects were divided into five groups according to the number of pack-years smoked: four groups of smokers classified as < 20, 20-39, 40-59, and > 60 pack-years and a control group. The four groups of smokers were compared with the control group using receiver operating characteristic (ROC) curves.
RESULTS: The early adverse effects of smoking in the group with < 20 pack-years were adequately detected by forced oscillation technique parameters. In this group, the comparisons of the ROC curves showed significantly better diagnostic accuracy (p < 0.01) for forced oscillation technique parameters. On the other hand, in groups of 20-39, 40-59, and > 60 pack-years, the diagnostic performance of the forced oscillation technique was similar to that observed with spirometry.
CONCLUSIONS: This study revealed that forced oscillation technique parameters were able to detect early smoking-induced respiratory involvement when pathologic changes are still potentially reversible. These findings support the use of the forced oscillation technique as a versatile clinical diagnostic tool in helping with chronic obstructive lung disease prevention, diagnosis, and treatment.
Alvaro Camilo Dias Faria; Alessandra Alves da Costa; Agnaldo Jose Lopes; Jose Manoel Jansen; Pedro Lopes de Melo
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinics (São Paulo, Brazil)     Volume:  65     ISSN:  1980-5322     ISO Abbreviation:  Clinics (Sao Paulo)     Publication Date:  2010  
Date Detail:
Created Date:  2011-02-22     Completed Date:  2011-08-10     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  101244734     Medline TA:  Clinics (Sao Paulo)     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  1295-304     Citation Subset:  IM    
Biomedical Instrumentation Laboratory, Institute of Biology, Faculty of Engineering, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
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MeSH Terms
Airway Resistance / physiology*
Case-Control Studies
Early Diagnosis
Pulmonary Disease, Chronic Obstructive / diagnosis*,  etiology
ROC Curve
Respiratory Function Tests / methods,  standards*
Respiratory Mechanics / physiology*
Sensitivity and Specificity
Smoking / adverse effects*,  physiopathology
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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