Document Detail

Forced normalization. Acute psychosis after seizure control in seven patients.
MedLine Citation:
PMID:  3103587     Owner:  NLM     Status:  MEDLINE    
An antagonistic relationship between psychosis and seizures has been described in some patients and is sometimes termed "forced normalization." We saw seven epileptic patients without a previous psychiatric history, who developed acute psychotic states on establishment of seizure control and normalization of previously abnormal electroencephalograms with frank epileptiform activity. A possible hypothetical relationship between psychosis and epilepsy regarding the mesolimbic dopaminergic system and kindling of this system with epileptic discharge in temporal-limbic circuits could induce a florid psychotic state in some patients. This biochemical relationship to schizophrenia with heightened dopamine activity would also easily explain the amelioration of acute psychotic activity in our seven patients with neuroleptic agents and their antagonism of this increased dopaminergic outflow state.
A Pakalnis; M E Drake; K John; J B Kellum
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of neurology     Volume:  44     ISSN:  0003-9942     ISO Abbreviation:  Arch. Neurol.     Publication Date:  1987 Mar 
Date Detail:
Created Date:  1987-03-30     Completed Date:  1987-03-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  289-92     Citation Subset:  AIM; IM    
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MeSH Terms
Anticonvulsants / therapeutic use*
Carbamazepine / therapeutic use
Epilepsy / complications*,  drug therapy
Haloperidol / therapeutic use*
Psychotic Disorders / drug therapy,  etiology*
Succinimides / therapeutic use
Valproic Acid / therapeutic use
Reg. No./Substance:
0/Anticonvulsants; 0/Succinimides; 298-46-4/Carbamazepine; 52-86-8/Haloperidol; 77-41-8/methsuximide; 99-66-1/Valproic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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