Document Detail

Forced exercise improves passive avoidance memory in morphine-exposed rats.
MedLine Citation:
PMID:  19943456     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to investigate the effect of short-term forced exercise protocol on passive avoidance retention in morphine-exposed rats. Effects of morphine on acquisition and retrieval of retention have been proven in the avoidance paradigms. Twenty four male Wistar rats weighing 250-300 g were used in this study. Animals were randomly divided into four groups including: (1) non-morphine-exposed without exercise (nA.nE) (2) non-morphine-exposed with exercise (nA.E) (3) morphine-exposed without exercise (A.nE) and (4) morphine-exposed with exercise (A.E). Rats ran as forced exercise on the motorized treadmill 1 h daily for ten days. Morphine-exposed animals received intraperitoneal morphine during first 5 days of the exercise period and their dependence to morphine was confirmed by naloxane admistration (10 mg kg(-1), i.p.) and withdrawal test. After 10 days of forced exercise, step down latency was tested and Inflexion Ratio (IR) was evaluated in each rat. Baseline step down latencies before any morphine exposing or exercise have shown no significant alteration in all groups. Inflexion Ratio (IR) ofnA.E group has increased significantly (p<0.001) at 1, 3, 7 and 14 days after receiving shock (learning) compared to nA.nE and A.E groups. Our data showed that short-term forced exercise on treadmill improved retention in both morphine-exposed and non morphine-exposed rats at least up to 7 days and more than 14 days, respectively. Alteration in retention between exercised groups may attribute the release of adrenal stress hormones such as epinephrine and corticosterone because of the emotional arousal.
K Saadipour; A Sarkaki; H Alaei; M Badavi; F Rahim
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pakistan journal of biological sciences: PJBS     Volume:  12     ISSN:  1028-8880     ISO Abbreviation:  Pak. J. Biol. Sci.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-11-30     Completed Date:  2010-01-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101247723     Medline TA:  Pak J Biol Sci     Country:  Pakistan    
Other Details:
Languages:  eng     Pagination:  1206-11     Citation Subset:  IM    
Physiology Research Center, Department of Physiology, Medicine Faculty, Ahwaz Jondishapour University of Medical Sciences, Ahwaz, Iran.
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MeSH Terms
Analgesics, Opioid / pharmacology*
Avoidance Learning / drug effects*,  physiology
Memory / drug effects*,  physiology
Morphine / pharmacology*
Physical Conditioning, Animal*
Random Allocation
Rats, Wistar
Reg. No./Substance:
0/Analgesics, Opioid; 57-27-2/Morphine

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