Document Detail

Forced exercise does not improve recovery after hemorrhagic stroke in rats.
MedLine Citation:
PMID:  16854389     Owner:  NLM     Status:  MEDLINE    
Exercise can improve recovery following ischemia and intracerebral hemorrhage (ICH) in rodents. We tested whether forced exercise (EX; running wheel) prior to and/or following ICH in rats would reduce lesion volume and improve functional outcome (walking, skilled reaching, spontaneous paw usage) at 7 weeks post-ICH. A striatal hemorrhage was produced by infusing collagenase. First, we compared animals that received EX (2 weeks; 1 h/day) ending two days prior to ICH and/or starting two weeks following ICH. EX did not improve functional recovery or affect lesion size. Doubling the amount of EX given per day (two 1-h sessions) both prior to and following ICH did not alter lesion volume, but worsened recovery. We then determined if EX (1 h/day) prior to and following ICH would affect outcome after a somewhat milder insult. There were no differences between the groups in lesion volume or recovery. Finally, we used a hemoglobin assay at 12 h following ICH to determine if pre-stroke EX (2 weeks; 1 h/day) aggravated bleeding. It did not. These observations suggest that EX does not improve outcome when given prior to and/or when delayed following ICH. Effective rehabilitation for ICH will likely require more complex interventions than forced running.
Angela M Auriat; Jennifer D Grams; Reginia H Yan; Frederick Colbourne
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-07-18
Journal Detail:
Title:  Brain research     Volume:  1109     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-29     Completed Date:  2006-10-31     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  183-91     Citation Subset:  IM    
Department of Psychology, University of Alberta, Edmonton, AB, Canada.
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MeSH Terms
Analysis of Variance
Behavior, Animal
Disease Models, Animal
Food Deprivation / physiology
Functional Laterality / physiology
Intracranial Hemorrhages / chemically induced,  complications,  rehabilitation
Motor Activity / physiology
Physical Conditioning, Animal / methods*
Psychomotor Performance / physiology
Rats, Long-Evans
Recovery of Function / physiology*
Stroke / etiology,  pathology,  rehabilitation*
Time Factors
Reg. No./Substance:
EC 3.4.24.-/Collagenases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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