| Forced exercise does not improve recovery after hemorrhagic stroke in rats. | |
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MedLine Citation:
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PMID: 16854389 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Exercise can improve recovery following ischemia and intracerebral hemorrhage (ICH) in rodents. We tested whether forced exercise (EX; running wheel) prior to and/or following ICH in rats would reduce lesion volume and improve functional outcome (walking, skilled reaching, spontaneous paw usage) at 7 weeks post-ICH. A striatal hemorrhage was produced by infusing collagenase. First, we compared animals that received EX (2 weeks; 1 h/day) ending two days prior to ICH and/or starting two weeks following ICH. EX did not improve functional recovery or affect lesion size. Doubling the amount of EX given per day (two 1-h sessions) both prior to and following ICH did not alter lesion volume, but worsened recovery. We then determined if EX (1 h/day) prior to and following ICH would affect outcome after a somewhat milder insult. There were no differences between the groups in lesion volume or recovery. Finally, we used a hemoglobin assay at 12 h following ICH to determine if pre-stroke EX (2 weeks; 1 h/day) aggravated bleeding. It did not. These observations suggest that EX does not improve outcome when given prior to and/or when delayed following ICH. Effective rehabilitation for ICH will likely require more complex interventions than forced running. |
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Authors:
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Angela M Auriat; Jennifer D Grams; Reginia H Yan; Frederick Colbourne |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2006-07-18 |
Journal Detail:
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Title: Brain research Volume: 1109 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-08-29 Completed Date: 2006-10-31 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 183-91 Citation Subset: IM |
Affiliation:
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Department of Psychology, University of Alberta, Edmonton, AB, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Behavior, Animal Collagenases Disease Models, Animal Food Deprivation / physiology Functional Laterality / physiology Intracranial Hemorrhages / chemically induced, complications, rehabilitation Male Motor Activity / physiology Physical Conditioning, Animal / methods* Psychomotor Performance / physiology Rats Rats, Long-Evans Recovery of Function / physiology* Stroke / etiology, pathology, rehabilitation* Time Factors |
| Chemical | |
Reg. No./Substance:
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EC 3.4.24.-/Collagenases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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