| Force transmission in the organ of Corti micromachine. | |
| | |
MedLine Citation:
|
PMID: 20550893 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Auditory discrimination is limited by the performance of the cochlea whose acute sensitivity and frequency tuning are underpinned by electromechanical feedback from the outer hair cells. Two processes may underlie this feedback: voltage-driven contractility of the outer hair cell body and active motion of the hair bundle. Either process must exert its mechanical effect via deformation of the organ of Corti, a complex assembly of sensory and supporting cells riding on the basilar membrane. Using finite element analysis, we present a three-dimensional model to illustrate deformation of the organ of Corti by the two active processes. The model used available measurements of the properties of structural components in low-frequency and high-frequency regions of the rodent cochlea. The simulations agreed well with measurements of the cochlear partition stiffness, the longitudinal space constant for point deflection, and the deformation of the organ of Corti for current injection, as well as displaying a 20-fold increase in passive resonant frequency from apex to base. The radial stiffness of the tectorial membrane attachment was found to be a crucial element in the mechanical feedback. Despite a substantial difference in the maximum force generated by hair bundle and somatic motility, the two mechanisms induced comparable amplitudes of motion of the basilar membrane but differed in the polarity of their feedback on hair bundle position. Compared to the hair bundle motor, the somatic motor was more effective in deforming the organ of Corti than in displacing the basilar membrane. |
| | |
Authors:
|
Jong-Hoon Nam; Robert Fettiplace |
Related Documents
:
|
20068613 - The spectral emissivity of the anode of a carbon arc. 2045583 - Evidence for the influence of aging on distortion-product otoacoustic emissions in humans. 1827833 - Imagined haptic exploration in judgments of object properties. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
|
Title: Biophysical journal Volume: 98 ISSN: 1542-0086 ISO Abbreviation: Biophys. J. Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-06-16 Completed Date: 2010-09-13 Revised Date: 2011-08-01 |
Medline Journal Info:
|
Nlm Unique ID: 0370626 Medline TA: Biophys J Country: United States |
Other Details:
|
Languages: eng Pagination: 2813-21 Citation Subset: IM |
Copyright Information:
|
(c) 2010 Biophysical Society. Published by Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Physiology, University of Wisconsin Medical School, Madison, Wisconsin, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Basilar Membrane / physiology Biomechanics Finite Element Analysis Models, Biological* Movement Organ of Corti / cytology, physiology* Tectorial Membrane / physiology |
| Grant Support | |
ID/Acronym/Agency:
|
R01 DC 01362/DC/NIDCD NIH HHS; R01 DC001362-16/DC/NIDCD NIH HHS; R01 DC001362-17/DC/NIDCD NIH HHS; R01 DC001362-18/DC/NIDCD NIH HHS; R01 DC001362-20/DC/NIDCD NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Multiscale morphology of organic semiconductor thin films controls the adhesion and viability of hum...
Next Document: Analysis of video-based microscopic particle trajectories using Kalman filtering.