Document Detail


Force requirements and insulin delivery profiles of four injection devices.
MedLine Citation:
PMID:  16120038     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Injection force requirements for four insulin pen-type injection devices were evaluated using the AGS-IkNG Autograph force measurement device (Shimadzu Corp., Kyoto, Japan). RESULTS: Compared with the Humulin Pen (the Japanese brand name is Humacart kit; the same device as the Humalog Pen; Eli Lilly, Indianapolis, IN), HumaPen Ergo (Eli Lilly), and NovoPen 3 (Novo Nordisk A/S, Bagsvaerd, Denmark), the InnoLet(Novo Nordisk) required the lowest injection force to both initiate piston movement and commence insulin delivery and required the lowest overall force throughout delivery. InnoLet and NovoPen 3 showed the most even load-displacement curves, suggesting a smoother delivery of insulin during injection. In contrast, the Humulin Pen and HumaPen Ergo demonstrated marked fluctuations in the force required to complete injection. CONCLUSIONS: These performance characteristics appeared consistent with mechanical features of these insulin delivery devices, and the results highlight the potential importance of careful pen selection for patients with neuromuscular weakness or impaired manual coordination.
Authors:
Kenichi Toraishi; Yoichi Yuizono; Noriko Nakamura; Shino Kato; Tsuyoshi Aoki; Kenji Ashida; Yasuhiro Sako
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Diabetes technology & therapeutics     Volume:  7     ISSN:  1520-9156     ISO Abbreviation:  Diabetes Technol. Ther.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-08-25     Completed Date:  2005-11-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100889084     Medline TA:  Diabetes Technol Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  629-35     Citation Subset:  IM    
Affiliation:
Department of Pharmacy, Saiseikai Fukuoka General Hospital, 1-3-46 Tenjin, Cho-ku, Fukuoka Prefecture, 810-0001 Fukuoka, Japan. toraishi@saiseikai-hp.chuo.fukuoka.jp
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MeSH Terms
Descriptor/Qualifier:
Diabetes Mellitus / drug therapy
Equipment Design
Humans
Injections, Subcutaneous / instrumentation*,  methods*,  standards
Insulin / administration & dosage*,  therapeutic use
Stress, Mechanical*
Chemical
Reg. No./Substance:
11061-68-0/Insulin
Comments/Corrections
Comment In:
Diabetes Technol Ther. 2005 Aug;7(4):636-7   [PMID:  16120039 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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