Document Detail


Force generation by actin polymerization II: the elastic ratchet and tethered filaments.
MedLine Citation:
PMID:  12609863     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The motion of many intracellular pathogens is driven by the polymerization of actin filaments. The propulsive force developed by the polymerization process is thought to arise from the thermal motions of the polymerizing filament tips. Recent experiments suggest that the nucleation of actin filaments involves a phase when the filaments are attached to the pathogen surface by a protein complex. Here we extend the "elastic ratchet model" of Mogilner and Oster to incorporate these new findings. We apply this "tethered ratchet" model to derive the force-velocity relation for Listeria and discuss relations of our theoretical predictions to experimental measurements. We also discuss "symmetry breaking" dynamics observed in ActA-coated bead experiments, and the implications of the model for lamellipodial protrusion in migrating cells.
Authors:
Alex Mogilner; George Oster
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Validation Studies    
Journal Detail:
Title:  Biophysical journal     Volume:  84     ISSN:  0006-3495     ISO Abbreviation:  Biophys. J.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-02-28     Completed Date:  2003-11-04     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  0370626     Medline TA:  Biophys J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1591-605     Citation Subset:  IM    
Affiliation:
Department of Mathematics and Center for Genetics and Development, University of California, Davis 95616, USA.
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MeSH Terms
Descriptor/Qualifier:
Actins / chemistry*
Bacterial Proteins / chemistry,  physiology
Coated Materials, Biocompatible
Computer Simulation
Elasticity
Listeria / chemistry*,  physiology*
Macromolecular Substances
Microspheres
Models, Biological*
Models, Molecular*
Molecular Motor Proteins / chemistry*,  physiology*
Motion
Polymers / chemistry
Protein Conformation
Stochastic Processes
Stress, Mechanical
Grant Support
ID/Acronym/Agency:
GM59875-02/GM/NIGMS NIH HHS; U54 GM64346/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Actins; 0/Bacterial Proteins; 0/Coated Materials, Biocompatible; 0/Macromolecular Substances; 0/Molecular Motor Proteins; 0/Polymers
Comments/Corrections

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