| Force generation by actin polymerization II: the elastic ratchet and tethered filaments. | |
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MedLine Citation:
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PMID: 12609863 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The motion of many intracellular pathogens is driven by the polymerization of actin filaments. The propulsive force developed by the polymerization process is thought to arise from the thermal motions of the polymerizing filament tips. Recent experiments suggest that the nucleation of actin filaments involves a phase when the filaments are attached to the pathogen surface by a protein complex. Here we extend the "elastic ratchet model" of Mogilner and Oster to incorporate these new findings. We apply this "tethered ratchet" model to derive the force-velocity relation for Listeria and discuss relations of our theoretical predictions to experimental measurements. We also discuss "symmetry breaking" dynamics observed in ActA-coated bead experiments, and the implications of the model for lamellipodial protrusion in migrating cells. |
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Authors:
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Alex Mogilner; George Oster |
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Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Validation Studies |
Journal Detail:
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Title: Biophysical journal Volume: 84 ISSN: 0006-3495 ISO Abbreviation: Biophys. J. Publication Date: 2003 Mar |
Date Detail:
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Created Date: 2003-02-28 Completed Date: 2003-11-04 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0370626 Medline TA: Biophys J Country: United States |
Other Details:
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Languages: eng Pagination: 1591-605 Citation Subset: IM |
Affiliation:
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Department of Mathematics and Center for Genetics and Development, University of California, Davis 95616, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Actins
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chemistry* Bacterial Proteins / chemistry, physiology Coated Materials, Biocompatible Computer Simulation Elasticity Listeria / chemistry*, physiology* Macromolecular Substances Microspheres Models, Biological* Models, Molecular* Molecular Motor Proteins / chemistry*, physiology* Motion Polymers / chemistry Protein Conformation Stochastic Processes Stress, Mechanical |
| Grant Support | |
ID/Acronym/Agency:
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GM59875-02/GM/NIGMS NIH HHS; U54 GM64346/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Actins; 0/Bacterial Proteins; 0/Coated Materials, Biocompatible; 0/Macromolecular Substances; 0/Molecular Motor Proteins; 0/Polymers |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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