| Force Oscillations Simulating Breathing Maneuvers do not Prevent Force Adaptation. | |
| | |
MedLine Citation:
|
PMID: 22323367 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Airway inflammation in asthmatics exposes the airway smooth muscle (ASM) to a variety of spasmogens. These spasmogens increase ASM tone, which can lead to force adaptation. It has been shown that length oscillations of ASM, which occur in vivo due to breathing maneuvers, can attenuate force adaptation. However, in the presence of tone, the force oscillations required to achieve these length oscillations may be unphysiologic. Herein, we applied force oscillations simulating the tension oscillations experienced by the airway wall during tidal breathing with or without deep inspirations (DI) to ASM. The goal was to investigate whether force adaptation occurs in conditions mimicking breathing maneuvers. Tone was induced by carbachol (average of 20nM) and the force-generating capacity of the ASM was assessed at 5-min intervals before and after carbachol administration using electrical field stimulations (EFS). The results show that force oscillations applied prior to the introduction of tone had a small effect on the force produced by EFS (declined to 96.8%, p>0.05, and 92.3%, p<0.05, with and without DI respectively). The tone induced by carbachol transiently decreased after a DI and declined significantly (p<0.05) due to tidal breathing oscillations (25%). However, these force oscillations did not prevent force adaptation (gain of force of 11.2 ± 2.2 vs. 13.5 ± 2.7 and 11.2 ± 3.0% in static vs. dynamic conditions with or without DI respectively). The lack of effect of simulated breathing maneuvers on force adaptation suggests that this gain in ASM-force may occur in vivo and could contribute to airway hyperresponsiveness. |
| | |
Authors:
|
Chris Pascoe; Yuekan Jiao; Chun Y Seow; Peter D Paré; Ynuk Bossé |
Related Documents
:
|
14683087 - Bursting and large-scale intermittency in turbulent convection with differential rotation. 18240967 - Control of lunar and martian dust--experimental insights from artificial and natural cy... 12697557 - A study of orientation in a zero gravity environment by means of virtual reality simula... 3567107 - Attachment-detachment, directiveness-receptiveness: a system for classifying interperso... 3617507 - Separation and light adaptation of rod and cone signals in the retina of the goldfish. 10615467 - Influence of body roll on visually induced sensations of self-tilt and rotation. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-2-9 |
Journal Detail:
|
Title: American journal of respiratory cell and molecular biology Volume: - ISSN: 1535-4989 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
|
Created Date: 2012-2-10 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8917225 Medline TA: Am J Respir Cell Mol Biol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
University of British Columbia James Hogg Research Center, St. Paul's Hospital, Vancouver, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A PAI-1 inhibitor reduces airway remodeling in a murine model of chronic asthma.
Next Document: Electroacupuncture alleviates affective pain in an inflammatory pain rat model.