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Food and water consumption in assessment of acute oral toxicity of HEPALIP FORTE in rats.
MedLine Citation:
PMID:  16232138     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Body weight variations during toxicological testing can be one of the indicators of the test substance toxic effects. Data on food and water consumption are true indicators of the rate of growth of experimental animals (Stevens & Gallo, 1989). Daily recording of the food and water consumption was done during the acute toxicity testing of HEPALIP FORTE. The study was performed on Wistar rats. The active component of HEPALIP FORTE is EPL substance--essential phospholipids, a natural substance present in every living cell. Essential phospholipids in combination with vitamins have been used in the treatment of liver diseases, dyslipoproteinaemias and intoxications accompanied with liver failure. Statistical analysis of the body weight variations was performed separately, for males and females. The analysis failed to show any significant difference between the groups. There was a significant difference in water consumption between the male group 2M and female groups 3F and 2F in comparison with control groups. Statistical analysis of the variations of food consumption showed a significant difference in all male groups in comparison with control groups, and only in the 3F female group in comparison with a control group. Considering the absence of lethality and the lack of significant influence of the test substance on animal body weights, we concluded that the test substance was not acutely toxic in rats, if applied orally, in single doses of 300 mg/kg, 500 mg/kg and 1000 mg/kg. Significant differences found in food and water consumption suggest a need of their during the future chronic toxicity testing.
Maida Todić; Sanela Bakić; Begler Begović; Sanja Krosnjar; Irfan Zulić
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bosnian journal of basic medical sciences / Udruženje basičnih mediciniskih znanosti = Association of Basic Medical Sciences     Volume:  3     ISSN:  1512-8601     ISO Abbreviation:  Bosn J Basic Med Sci     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2005-10-19     Completed Date:  2005-10-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101200947     Medline TA:  Bosn J Basic Med Sci     Country:  Bosnia and Hercegovina    
Other Details:
Languages:  eng     Pagination:  47-53     Citation Subset:  -    
Institute of Pharmacology and Toxicology Pavel Stern , Faculty of Medicine, Sarajevo.
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