Document Detail


Systems toxicology.
MedLine Citation:
PMID:  22562485     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The need for a more mechanistic understanding of the ways in which chemicals modulate biological pathways is urgent if we are to identify and better assess safety issues relating to a wide range of substances developed by the pharmaceutical, chemical, agri-bio, and cosmetic industries. Omics technologies provide a valuable opportunity to refine existing methods and provide information for so-called integrated testing strategies via the creation of signatures of toxicity. By mapping these signatures to underlying pathways of toxicity, some of which have been identified by toxicologists over the last few decades, and bringing them together with pathway information determined from biochemistry and molecular biology, a "systems toxicology" approach will enable virtual experiments to be conducted that can improve the prediction of hazard and the assessment of compound toxicity.
Authors:
Thomas Hartung; Erwin van Vliet; Joanna Jaworska; Leo Bonilla; Nigel Skinner; Russell Thomas
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  ALTEX     Volume:  29     ISSN:  1868-596X     ISO Abbreviation:  ALTEX     Publication Date:  2012  
Date Detail:
Created Date:  2012-05-07     Completed Date:  2012-09-05     Revised Date:  2013-02-11    
Medline Journal Info:
Nlm Unique ID:  100953980     Medline TA:  ALTEX     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  119-28     Citation Subset:  IM    
Affiliation:
Johns Hopkins University, Bloomberg School of Public Health, Center for Alternatives to Animal Testing (CAAT), Baltimore, MD 21205, USA. thartung@jhsph.edu
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MeSH Terms
Descriptor/Qualifier:
Agrochemicals
Animal Testing Alternatives
Animals
Chemical Industry
Computational Biology
Cosmetics
Databases, Factual
Gene Expression Regulation / drug effects
Humans
Pharmaceutical Preparations
Proteomics
Systems Biology / methods*
Toxicology / methods*
Transcriptome
Chemical
Reg. No./Substance:
0/Agrochemicals; 0/Cosmetics; 0/Pharmaceutical Preparations

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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