Document Detail


Food for thought ... Alternative approaches for medical countermeasures to biological and chemical terrorism and warfare.
MedLine Citation:
PMID:  22847253     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The desire to develop and evaluate drugs as potential countermeasures for biological and chemical threats requires test systems that can also substitute for the clinical trials normally crucial for drug development. Animal models have limited predictivity for drug efficacy, as is well known from many disappointments in clinical trials. Traditional in vitro and in silico approaches are not really game changers here, but the substantial investment into novel tools now underway might bring about a second generation of alternative approaches. The avenue pursued focuses primarily on the development of a Human on a Chip, i.e., the combination of different three-dimensional (stem) cell-based organ equivalents combined with microfluidics. The prospects of such approaches, their impact on the field of alternative approaches, and necessary complementary activities are discussed. The need to adapt quality assurance measures and experiences from validation is stressed.
Authors:
Thomas Hartung; Joanne Zurlo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  ALTEX     Volume:  29     ISSN:  1868-596X     ISO Abbreviation:  ALTEX     Publication Date:  2012  
Date Detail:
Created Date:  2012-07-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100953980     Medline TA:  ALTEX     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  251-60     Citation Subset:  IM    
Affiliation:
Johns Hopkins University, Bloomberg School of Public Health, Center for Alternatives to Animal Testing (CAAT), Baltimore, USA and University of Konstanz, CAAT-Europe, Germany;
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