Document Detail

Food-specific IgG4-guided exclusion diets improve symptoms in Crohn's disease: a pilot study.
MedLine Citation:
PMID:  20626437     Owner:  NLM     Status:  In-Data-Review    
Aim  Exclusion diets have been shown to prolong remission in Crohn's disease (CD). We assessed IgG4-targeted exclusion diets in patients with CD. Method  Forty patients with symptomatic CD were recruited. Their sera were tested for IgG4 antibodies to 14 specific food antigens and each subject's four most reactive foods were excluded for 4 weeks. Disease activity was assessed using a modified CD activity index (mCDAI). Questionnaire and inflammatory markers were measured before and on completion of the exclusion diet. Results  Eleven patients did not complete the study, leaving 29 for analysis. Of these, 26 (90%) reported symptomatic improvement with a reduction in mCDAI from a mean of 171-97.5 (P = 0.0001). The ESR fell from 23 to 17 mm/h (P = 0.021) and the IgG4 titres for the excluded foods fell from a mean of 3015-2306 mcgA/l (P = 0.003). Conclusion  IgG4-guided exclusion diets resulted in significant symptomatic improvement with an objective fall in an inflammatory marker. This approach may be useful in clinical practice.
N Rajendran; D Kumar
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Publication Detail:
Type:  Journal Article     Date:  2010-07-07
Journal Detail:
Title:  Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland     Volume:  13     ISSN:  1463-1318     ISO Abbreviation:  Colorectal Dis     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883611     Medline TA:  Colorectal Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  1009-13     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors. Colorectal Disease © 2011 The Association of Coloproctology of Great Britain and Ireland.
St George's Hospital, London, UK.
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