Document Detail


Food reward in the absence of taste receptor signaling.
MedLine Citation:
PMID:  18367093     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Food palatability and hedonic value play central roles in nutrient intake. However, postingestive effects can influence food preferences independently of palatability, although the neurobiological bases of such mechanisms remain poorly understood. Of central interest is whether the same brain reward circuitry that is responsive to palatable rewards also encodes metabolic value independently of taste signaling. Here we show that trpm5-/- mice, which lack the cellular machinery required for sweet taste transduction, can develop a robust preference for sucrose solutions based solely on caloric content. Sucrose intake induced dopamine release in the ventral striatum of these sweet-blind mice, a pattern usually associated with receipt of palatable rewards. Furthermore, single neurons in this same ventral striatal region showed increased sensitivity to caloric intake even in the absence of gustatory inputs. Our findings suggest that calorie-rich nutrients can directly influence brain reward circuits that control food intake independently of palatability or functional taste transduction.
Authors:
Ivan E de Araujo; Albino J Oliveira-Maia; Tatyana D Sotnikova; Raul R Gainetdinov; Marc G Caron; Miguel A L Nicolelis; Sidney A Simon
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuron     Volume:  57     ISSN:  1097-4199     ISO Abbreviation:  Neuron     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-27     Completed Date:  2008-04-28     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  8809320     Medline TA:  Neuron     Country:  United States    
Other Details:
Languages:  eng     Pagination:  930-41     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / drug effects,  physiology,  radiation effects
Analysis of Variance
Animals
Behavior, Animal
Blood Glucose / physiology
Choice Behavior / physiology
Conditioning, Operant / physiology
Dopamine / metabolism
Dose-Response Relationship, Drug
Food Preferences / physiology*
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Neurons / drug effects,  physiology,  radiation effects
Nucleus Accumbens / cytology
Reward*
Signal Transduction / physiology*
Statistics, Nonparametric
Stimulation, Chemical
Sucrose / administration & dosage
Sweetening Agents / administration & dosage
TRPM Cation Channels / deficiency,  physiology*
Grant Support
ID/Acronym/Agency:
DC-01065/DC/NIDCD NIH HHS
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Sweetening Agents; 0/TRPM Cation Channels; 0/Trpm5 protein, mouse; 57-50-1/Sucrose; VTD58H1Z2X/Dopamine
Comments/Corrections
Comment In:
Neuron. 2008 Mar 27;57(6):806-8   [PMID:  18367081 ]
Erratum In:
Neuron. 2008 Apr 24;58(2):295

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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