| Food reward and cocaine increase extracellular dopamine in the nucleus accumbens as measured by microdialysis. | |
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MedLine Citation:
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PMID: 3362036 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dopamine was measured by microdialysis in the nucleus accumbens of freely moving rats while they experienced rewarding food, brain stimulation and drugs. Extracellular dopamine increased 37% when the animals pressed a lever for food reward. Electrical stimulation of a lateral hypothalamic feeding-reward (self-stimulation) site caused a similar increase in dopamine, with or without food. At the site in the nucleus accumbens where rats will administer amphetamine to themselves, injections of amphetamine or cocaine increased extracellular dopamine five-fold. Thus amphetamine and cocaine increase dopamine in a behavior reinforcement system which is normally activated by eating. Conversely, the release of dopamine by eating could be a factor in addiction to food. |
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Authors:
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L Hernandez; B G Hoebel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Life sciences Volume: 42 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 1988 |
Date Detail:
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Created Date: 1988-06-03 Completed Date: 1988-06-03 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1705-12 Citation Subset: IM |
Affiliation:
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Department of Psychology, Princeton University, New Jersey 08544. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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3,4-Dihydroxyphenylacetic Acid
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metabolism Amphetamine / pharmacology Animals Cocaine / pharmacology* Dialysis Dopamine / metabolism* Eating Electric Stimulation Extracellular Space / metabolism Food* Homovanillic Acid / metabolism Hypothalamus / physiology Kinetics Male Nucleus Accumbens / drug effects, metabolism* Rats Rats, Inbred Strains Reinforcement (Psychology) Reward* Septal Nuclei / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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DA-03597/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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102-32-9/3,4-Dihydroxyphenylacetic Acid; 300-62-9/Amphetamine; 306-08-1/Homovanillic Acid; 50-36-2/Cocaine |
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