Document Detail

Food reward and cocaine increase extracellular dopamine in the nucleus accumbens as measured by microdialysis.
MedLine Citation:
PMID:  3362036     Owner:  NLM     Status:  MEDLINE    
Dopamine was measured by microdialysis in the nucleus accumbens of freely moving rats while they experienced rewarding food, brain stimulation and drugs. Extracellular dopamine increased 37% when the animals pressed a lever for food reward. Electrical stimulation of a lateral hypothalamic feeding-reward (self-stimulation) site caused a similar increase in dopamine, with or without food. At the site in the nucleus accumbens where rats will administer amphetamine to themselves, injections of amphetamine or cocaine increased extracellular dopamine five-fold. Thus amphetamine and cocaine increase dopamine in a behavior reinforcement system which is normally activated by eating. Conversely, the release of dopamine by eating could be a factor in addiction to food.
L Hernandez; B G Hoebel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Life sciences     Volume:  42     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1988  
Date Detail:
Created Date:  1988-06-03     Completed Date:  1988-06-03     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1705-12     Citation Subset:  IM    
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MeSH Terms
3,4-Dihydroxyphenylacetic Acid / metabolism
Amphetamine / pharmacology
Cocaine / pharmacology*
Dopamine / metabolism*
Electric Stimulation
Extracellular Space / metabolism
Homovanillic Acid / metabolism
Hypothalamus / physiology
Nucleus Accumbens / drug effects,  metabolism*
Rats, Inbred Strains
Reinforcement (Psychology)
Septal Nuclei / metabolism*
Grant Support
Reg. No./Substance:
102-32-9/3,4-Dihydroxyphenylacetic Acid; CK833KGX7E/Amphetamine; I5Y540LHVR/Cocaine; VTD58H1Z2X/Dopamine; X77S6GMS36/Homovanillic Acid

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