Document Detail


Food restriction prevents age-related polyuria by vasopressin-dependent recruitment of aquaporin-2.
MedLine Citation:
PMID:  11704564     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mechanisms underlying the prevention of age-related polyuria by chronic food restriction were investigated in female WAG/Rij rats. The decreased osmolality of renal papilla observed in senescent rats was not corrected by food restriction. A reduced urea content in the inner medulla of senescent rats, fed ad libitum or food-restricted, was suggested by the marked decrease in expression of UT-A1 and UT-B1 urea transporters. Aquaporin-2 (AQP2) downregulation in the inner medulla of senescent rats was partially prevented by food restriction. Both AQP2 and the phosphorylated form of AQP2 (p-AQP2), the presence of which was diffuse within the cytoplasm of collecting duct principal cells in normally fed senescent rats, were preferentially targeted at the apical region of the cells in food-restricted senescent animals. Plasma vasopressin (AVP) was similar in 10- and 30-mo-old rats fed ad libitum, but was doubled in food-restricted 30-mo-old rats. This study indicates that 1) kidney aging is associated with a marked decrease in AQP2, UT-A1, and UT-B1 expression in the inner medulla and a reduced papillary osmolality; and 2) the prevention of age-related polyuria by chronic food restriction occurs through an improved recruitment of AQP2 and p-AQP2 to the apical membrane in inner medulla principal cells, permitted by increased plasma AVP concentration.
Authors:
S Combet; L Teillet; G Geelen; B Pitrat; R Gobin; S Nielsen; M M Trinh-Trang-Tan; B Corman; J M Verbavatz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of physiology. Renal physiology     Volume:  281     ISSN:  1931-857X     ISO Abbreviation:  Am. J. Physiol. Renal Physiol.     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-11-12     Completed Date:  2001-12-27     Revised Date:  2011-04-28    
Medline Journal Info:
Nlm Unique ID:  100901990     Medline TA:  Am J Physiol Renal Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  F1123-31     Citation Subset:  IM    
Affiliation:
Service de Biologie Cellulaire, Commissariat à l'Energie Atomique/Saclay, F-91191 Gif-sur-Yvette, France.
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MeSH Terms
Descriptor/Qualifier:
Aging*
Animals
Aquaporin 2
Aquaporin 6
Aquaporins / metabolism*
Carrier Proteins / metabolism
Cell Polarity
Eating*
Female
Kidney / metabolism*
Kidney Medulla / chemistry,  metabolism,  ultrastructure
Kidney Tubules / metabolism,  ultrastructure
Membrane Glycoproteins / metabolism
Membrane Transport Proteins*
Osmolar Concentration
Phosphorylation
Polyuria / etiology,  metabolism,  prevention & control*
Protein Transport
Rats
Urine / chemistry
Vasopressins / blood,  physiology*
Water-Electrolyte Imbalance / etiology,  metabolism
Chemical
Reg. No./Substance:
0/Aqp2 protein, rat; 0/Aquaporin 2; 0/Aquaporin 6; 0/Aquaporins; 0/Carrier Proteins; 0/Membrane Glycoproteins; 0/Membrane Transport Proteins; 0/urea transporter; 11000-17-2/Vasopressins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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