Document Detail


Food restriction-induced hyperactivity: Addiction or adaptation to famine?
MedLine Citation:
PMID:  23059205     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Increased physical activity is present in 30-80% of anorexia nervosa patients. To explain the paradox of low food intake and excessive exercise in humans and other animals, it has been proposed that increased physical activity along with food restriction activates brain reward circuits and is addictive. Alternatively, the fleeing-famine hypothesis postulates that refusal of known scarce energy-low food sources and hyperactivity facilitate migration towards new habitats that potentially contain new energy-rich foodstuffs. The use of rewarding compounds that differ in energy density, such as the energy-free sweetener saccharin and the energy rich sucrose makes it possible to critically test the reward-addiction and fleeing-famine hypotheses. The aims of the present work were to study if sucrose and/or saccharin could attenuate food restriction-induced hyperactivity, weight loss, increased plasma corticosterone, and activation of brain structures involved in neuroendocrine control, energy balance, physical activity, and reward signaling in rats. Its major findings are that access to sucrose, but not to saccharin, attenuated food restriction-induced running wheel activity, weight loss, rises in plasma corticosterone, and expression of the cellular activation marker c-Fos in the paraventricular and arcuate hypothalamus and in the nucleus accumbens. These findings suggest that the energy-richness and easy availability of sucrose interrupted a fleeing-famine-like hyperactivity response. Since corticosterone mediates food restriction-induced wheel running (Duclos et al., 2009), we propose that the attenuating effect of sucrose consumption on plasma corticosterone plays a role in reduced wheel running and weight loss by lowering activation of the nucleus accumbens and arcuate hypothalamus in these animals.
Authors:
Martine Duclos; Amel Ouerdani; Pierre Mormède; Jan Pieter Konsman
Related Documents :
15261415 - Seasonal variation in the composition and concentration of butyltin compounds in marine...
16151605 - Environmental factors influencing the seasonality of estrus in chimpanzees.
23380045 - Dairy-food, calcium, magnesium, and vitamin d intake and endometriosis: a prospective c...
16458335 - Food restriction affects reproduction and survival of f1 and f2 offspring of rat-like h...
16934895 - Information systems in food safety management.
16564585 - Real-time pcr for the detection of salmonella spp. in food: an alternative approach to ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-8
Journal Detail:
Title:  Psychoneuroendocrinology     Volume:  -     ISSN:  1873-3360     ISO Abbreviation:  Psychoneuroendocrinology     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7612148     Medline TA:  Psychoneuroendocrinology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, F-63000 Clermont-Ferrand, France; INRA, UMR 1019, UNH, CRNH Auvergne, F-63000 Clermont-Ferrand, France; CHU Clermont-Ferrand, Service de Médecine du Sport et des Explorations Fonctionnelles, F-63003 Clermont-Ferrand, France; CNRS, UMR 5226, PsychoNeuroImmunologie, Nutrition et Génétique, University Bordeaux, F-33076 Bordeaux, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Triazole-acridine conjugates: Redox mechanisms and in situ electrochemical evaluation of interaction...
Next Document:  Neurobehavioral assessment in forensic practice.