Document Detail

Food restriction increases acquisition, persistence and drug prime-induced expression of a cocaine-conditioned place preference in rats.
MedLine Citation:
PMID:  22074687     Owner:  NLM     Status:  MEDLINE    
Cocaine conditioned place preference (CPP) is more persistent in food-restricted than ad libitum fed rats. This study assessed whether food restriction acts during conditioning and/or expression to increase persistence. In Experiment 1, rats were food-restricted during conditioning with a 7.0 mg/kg (i.p.) dose of cocaine. After the first CPP test, half of the rats were switched to ad libitum feeding for three weeks, half remained on food restriction, and this was followed by CPP testing. Rats tested under the ad libitum feeding condition displayed extinction by the fifth test. Their CPP did not reinstate in response to overnight food deprivation or a cocaine prime. Rats maintained on food restriction displayed a persistent CPP. In Experiment 2, rats were ad libitum fed during conditioning with the 7.0 mg/kg dose. In the first test only a trend toward CPP was displayed. Rats maintained under the ad libitum feeding condition did not display a CPP during subsequent testing and did not respond to a cocaine prime. Rats tested under food-restriction also did not display a CPP, but expressed a CPP following a cocaine prime. In Experiment 3, rats were ad libitum fed during conditioning with a 12.0 mg/kg dose. After the first test, half of the rats were switched to food restriction for three weeks. Rats that were maintained under the ad libitum condition displayed extinction by the fourth test. Their CPP was not reinstated by a cocaine prime. Rats tested under food-restriction displayed a persistent CPP. These results indicate that food restriction lowers the threshold dose for cocaine CPP and interacts with a previously acquired CPP to increase its persistence. In so far as CPP models Pavlovian conditioning that contributes to addiction, these results suggest the importance of diet and the physiology of energy balance as modulatory factors.
Danielle Zheng; Soledad Cabeza de Vaca; Kenneth D Carr
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-10-29
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  100     ISSN:  1873-5177     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-19     Completed Date:  2012-05-04     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  538-44     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
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MeSH Terms
Behavior, Animal / drug effects
Caloric Restriction / adverse effects*
Cocaine / administration & dosage,  pharmacology
Cocaine-Related Disorders / diet therapy,  physiopathology*,  prevention & control,  psychology
Conditioning (Psychology)*
Dose-Response Relationship, Drug
Energy Intake
Exploratory Behavior / drug effects
Extinction, Psychological
Random Allocation
Rats, Sprague-Dawley
Recurrence / prevention & control
Reinforcement (Psychology)*
Grant Support
Reg. No./Substance:

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