| Food restriction and fish oil suppress atherogenic risk factors in lupus-prone (NZB x NZW) F1 mice. | |
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MedLine Citation:
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PMID: 12645857 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Atherosclerosis-mediated coronary artery disease is a significant cause of mortality in lupus patients. Both an activated immune system and hyperlipidemia are implicated in the pathogenesis of the atherosclerotic lesions of lupus. In this study, the increases in anticardiolipin antibodies, total cholesterol, and LDL cholesterol with age were significantly lowered by fish oil and food restriction, either alone or in combination. Food restriction also significantly decreased the elevation in anti-dsDNA antibody production seen with age in ad libitum groups. Interestingly, effects of food restriction and fish oil on both lipid profile and autoantibody production were seen from a young age. Accumulation of leukocytes in the blood vessels and deposition of IgG in the glomerular mesangium also were suppressed by food restriction. Thus, beneficial effects of fish oil and food restriction on lupus nephritis and survival could be, at least in part, due to their selective effect on atherogenic risk factors. |
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Authors:
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Alagarraju Muthukumar; Khaliquz Zaman; Richard Lawrence; Jeffery L Barnes; Gabriel Fernandes |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of clinical immunology Volume: 23 ISSN: 0271-9142 ISO Abbreviation: J. Clin. Immunol. Publication Date: 2003 Jan |
Date Detail:
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Created Date: 2003-03-20 Completed Date: 2003-12-10 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8102137 Medline TA: J Clin Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 23-33 Citation Subset: IM |
Affiliation:
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Department of Medicine, Division of Clinical Immunology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteriosclerosis / diet therapy, prevention & control* Caloric Restriction* Cholesterol / blood DNA / immunology Fish Oils / metabolism* Immunoglobulin G / blood, immunology Kidney / pathology, physiology Lupus Erythematosus, Systemic / diet therapy, metabolism* Mice Mice, Inbred NZB |
| Grant Support | |
ID/Acronym/Agency:
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AG14541/AG/NIA NIH HHS; AG20239/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fish Oils; 0/Immunoglobulin G; 57-88-5/Cholesterol; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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