Document Detail

Food restriction and fish oil suppress atherogenic risk factors in lupus-prone (NZB x NZW) F1 mice.
MedLine Citation:
PMID:  12645857     Owner:  NLM     Status:  MEDLINE    
Atherosclerosis-mediated coronary artery disease is a significant cause of mortality in lupus patients. Both an activated immune system and hyperlipidemia are implicated in the pathogenesis of the atherosclerotic lesions of lupus. In this study, the increases in anticardiolipin antibodies, total cholesterol, and LDL cholesterol with age were significantly lowered by fish oil and food restriction, either alone or in combination. Food restriction also significantly decreased the elevation in anti-dsDNA antibody production seen with age in ad libitum groups. Interestingly, effects of food restriction and fish oil on both lipid profile and autoantibody production were seen from a young age. Accumulation of leukocytes in the blood vessels and deposition of IgG in the glomerular mesangium also were suppressed by food restriction. Thus, beneficial effects of fish oil and food restriction on lupus nephritis and survival could be, at least in part, due to their selective effect on atherogenic risk factors.
Alagarraju Muthukumar; Khaliquz Zaman; Richard Lawrence; Jeffery L Barnes; Gabriel Fernandes
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of clinical immunology     Volume:  23     ISSN:  0271-9142     ISO Abbreviation:  J. Clin. Immunol.     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2003-03-20     Completed Date:  2003-12-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8102137     Medline TA:  J Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  23-33     Citation Subset:  IM    
Department of Medicine, Division of Clinical Immunology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900, USA.
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MeSH Terms
Arteriosclerosis / diet therapy,  prevention & control*
Caloric Restriction*
Cholesterol / blood
DNA / immunology
Fish Oils / metabolism*
Immunoglobulin G / blood,  immunology
Kidney / pathology,  physiology
Lupus Erythematosus, Systemic / diet therapy,  metabolism*
Mice, Inbred NZB
Grant Support
Reg. No./Substance:
0/Fish Oils; 0/Immunoglobulin G; 57-88-5/Cholesterol; 9007-49-2/DNA

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