Document Detail

Food restriction alters villi morphology in obese rats: gut mechanism for weight regain?
MedLine Citation:
PMID:  22956621     Owner:  NLM     Status:  MEDLINE    
Weight regain after a long-term weight-loss program is a greater problem in obesity treatment than is weight reduction. Hence, the gut may elevate the absorption rate and nutrient transportation remarkably during chronic food restriction. The extension of gut absorption may be one possible reason for weight regain. But there is little information about the mechanisms that regulate intestinal absorption during food restriction. In this study, we show that the surface absorptive areas of gut villi may be enlarged in the jejunum of rats maintained on a food restriction regimen compared with animals submitted to swimming or sedentary behavior. Our findings show that simply reducing the amount of food intake results in an increased appetite accompanied with obvious weight regain, and suggest that the resulting enlargement of villi surface areas plays a key role in the regain of weight reduction. These results bolster accumulating evidence that gut absorption may be a substantial mechanism for resistance of weight loss and enhancing the weight regain process.
Jian Gang Zhang; Xiao Wei Sun; Peng Gao; Lan Xie; Wen Qian Liu; Hai Tao Xiao; Hua Ai
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-09-06
Journal Detail:
Title:  Experimental biology and medicine (Maywood, N.J.)     Volume:  237     ISSN:  1535-3699     ISO Abbreviation:  Exp. Biol. Med. (Maywood)     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-19     Completed Date:  2012-11-29     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  100973463     Medline TA:  Exp Biol Med (Maywood)     Country:  England    
Other Details:
Languages:  eng     Pagination:  993-9     Citation Subset:  IM    
Institute of Sports Medicine, Third Hospital of Peking University, Beijing 100191, China.
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MeSH Terms
Body Weight / physiology
Caloric Restriction*
Diet, Reducing
Food Deprivation
Intestinal Absorption*
Intestinal Mucosa / physiology*
Intestines / physiology*
Jejunum / physiology
Obesity / diet therapy*,  physiopathology
Rats, Sprague-Dawley
Weight Gain
Weight Loss / physiology
Weight Reduction Programs

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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