Document Detail

Food-reinforced operant behavior in dopamine transporter knockout mice: enhanced resistance to extinction.
MedLine Citation:
PMID:  15542711     Owner:  NLM     Status:  MEDLINE    
Dopamine (DA) plays roles in circuits that are important for brain reward and in striatal brain regions that are important for certain types of habit learning. These processes in wildtype, heterozygous, and homozygous dopamine transporter knockout (DAT-KO) mice, which were mildly food deprived and allowed to make nose-poke responses for food reinforcement, were studied. The mice were given 20-min sessions of daily (a) baseline exposure to the operant chambers, (b) acquisition of nose-poke responses in which responses were reinforced under a fixed ratio (FR5) schedule, (c) a progressive ratio schedule in which the number of responses required to obtain food was gradually increased, and (d) extinction of responses in which nose pokes were not followed by food. Neither heterozygous nor homozygous DAT-KO mice differed from their wildtype litter mates in the number of nose pokes displayed during baseline exposures to the chambers, the number of sessions required for acquisition, the number of responses under the FR5 schedule, or the number of responses under the progressive ratio schedule. Interestingly, however, in the five extinction sessions in which food was no longer delivered by nose poking, homozygous DAT-KO mice exerted significantly more responses than mice of either of the other two genotypes. These lines of evidence suggest a greater resistance of DAT-KO mice to the elimination of the response and support roles of dopaminergic systems in habit memory.
Naoyuki Hironaka; Kazutaka Ikeda; Ichiro Sora; George R Uhl; Hiroaki Niki
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1025     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-11-15     Completed Date:  2005-02-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  140-5     Citation Subset:  IM    
Department of Psychology, Senshu University, Kawasaki, 214-8580 Japan.
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MeSH Terms
Conditioning, Operant / physiology*
Dopamine Plasma Membrane Transport Proteins
Eating / physiology*
Extinction, Psychological / physiology*
Membrane Glycoproteins / biosynthesis,  deficiency*,  genetics
Membrane Transport Proteins / biosynthesis,  deficiency*,  genetics
Mice, Knockout
Nerve Tissue Proteins / biosynthesis,  deficiency*,  genetics
Reinforcement Schedule*
Reg. No./Substance:
0/Dopamine Plasma Membrane Transport Proteins; 0/Membrane Glycoproteins; 0/Membrane Transport Proteins; 0/Nerve Tissue Proteins; 0/Slc6a3 protein, mouse

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