Document Detail


Food products made with glycomacropeptide, a low-phenylalanine whey protein, provide a new alternative to amino Acid-based medical foods for nutrition management of phenylketonuria.
MedLine Citation:
PMID:  22818728     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Phenylketonuria (PKU), an inborn error in phenylalanine metabolism, requires lifelong nutrition management with a low-phenylalanine diet, which includes a phenylalanine-free amino acid-based medical formula to provide the majority of an individual's protein needs. Compliance with this diet is often difficult for older children, adolescents, and adults with PKU. The whey protein glycomacropeptide (GMP) is ideally suited for the PKU diet because it is naturally low in phenylalanine. Nutritionally complete, acceptable medical foods and beverages can be made with GMP to increase the variety of protein sources for the PKU diet. As an intact protein, GMP improves protein use and increases satiety compared with amino acids. Thus, GMP provides a new, more physiologic source of low-phenylalanine dietary protein for people with PKU.
Authors:
Sandra C van Calcar; Denise M Ney
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of the Academy of Nutrition and Dietetics     Volume:  112     ISSN:  2212-2672     ISO Abbreviation:  J Acad Nutr Diet     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-23     Completed Date:  2012-09-27     Revised Date:  2013-08-12    
Medline Journal Info:
Nlm Unique ID:  101573920     Medline TA:  J Acad Nutr Diet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1201-10     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 Academy of Nutrition and Dietetics. Published by Elsevier Inc. All rights reserved.
Affiliation:
Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, WI 53703, USA.
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MeSH Terms
Descriptor/Qualifier:
Glycopeptides / therapeutic use*
Humans
Milk Proteins
Nutritional Requirements
Phenylalanine / adverse effects,  analysis
Phenylketonurias / diet therapy*
Treatment Outcome
Grant Support
ID/Acronym/Agency:
M01 RR003186/RR/NCRR NIH HHS; R01 FD003711/FD/FDA HHS; R03 DK071534/DK/NIDDK NIH HHS; UL1 RR025011/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Glycopeptides; 0/Milk Proteins; 0/whey protein; 63-91-2/Phenylalanine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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