Document Detail


Food presentation modifies longevity and the beneficial action of dietary restriction in Drosophila.
MedLine Citation:
PMID:  19895881     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent studies have indicated that flies respond to dilute food solutions by compensatory feeding. The existence of compensation mechanisms calls for a reconsideration of the relationships between diet, feeding behaviour and longevity. This study shows that flies fed on liquid diets, sense sucrose and yeast nutrients and adapt to changes in the quantity and presentation of the two nutrients. They have a marked preference for sucrose and regulate their sucrose intake more tightly than their yeast intake. These preferences are not modified as fly age from 1 to 30 days. Compensatory feeding suppresses the beneficial action of dietary restriction on longevity when flies are fed on liquid diets supplemented with yeast extracts. Flies which are given the choice to feed on separate yeast and sucrose food sources were longer lived than flies fed on nutrient mixtures. We conclude that flies sense and respond to specific nutrients and that food presentation is a major factor which determines the sensitivity of flies to dietary restriction.
Authors:
Paul Vigne; Christian Frelin
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-11-04
Journal Detail:
Title:  Experimental gerontology     Volume:  45     ISSN:  1873-6815     ISO Abbreviation:  Exp. Gerontol.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-01     Completed Date:  2010-04-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0047061     Medline TA:  Exp Gerontol     Country:  England    
Other Details:
Languages:  eng     Pagination:  113-8     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2009 Elsevier Inc. All rights reserved.
Affiliation:
Centre National de la Recherche Scientifique UMR 6543, Univ. Nice Sophia Antipolis, Parc Valrose. Nice, France.
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MeSH Terms
Descriptor/Qualifier:
Aging / physiology*
Animal Feed
Animals
Caloric Restriction*
Culture Media
Dietary Sucrose / pharmacology
Drosophila / physiology*
Feeding Behavior / physiology*
Longevity / physiology*
Mice
Yeasts
Chemical
Reg. No./Substance:
0/Culture Media; 0/Dietary Sucrose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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