| Food presentation modifies longevity and the beneficial action of dietary restriction in Drosophila. | |
| | |
MedLine Citation:
|
PMID: 19895881 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Recent studies have indicated that flies respond to dilute food solutions by compensatory feeding. The existence of compensation mechanisms calls for a reconsideration of the relationships between diet, feeding behaviour and longevity. This study shows that flies fed on liquid diets, sense sucrose and yeast nutrients and adapt to changes in the quantity and presentation of the two nutrients. They have a marked preference for sucrose and regulate their sucrose intake more tightly than their yeast intake. These preferences are not modified as fly age from 1 to 30 days. Compensatory feeding suppresses the beneficial action of dietary restriction on longevity when flies are fed on liquid diets supplemented with yeast extracts. Flies which are given the choice to feed on separate yeast and sucrose food sources were longer lived than flies fed on nutrient mixtures. We conclude that flies sense and respond to specific nutrients and that food presentation is a major factor which determines the sensitivity of flies to dietary restriction. |
| | |
Authors:
|
Paul Vigne; Christian Frelin |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-11-04 |
Journal Detail:
|
Title: Experimental gerontology Volume: 45 ISSN: 1873-6815 ISO Abbreviation: Exp. Gerontol. Publication Date: 2010 Feb |
Date Detail:
|
Created Date: 2010-02-01 Completed Date: 2010-04-13 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0047061 Medline TA: Exp Gerontol Country: England |
Other Details:
|
Languages: eng Pagination: 113-8 Citation Subset: IM |
Copyright Information:
|
Copyright (c) 2009 Elsevier Inc. All rights reserved. |
Affiliation:
|
Centre National de la Recherche Scientifique UMR 6543, Univ. Nice Sophia Antipolis, Parc Valrose. Nice, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aging
/
physiology* Animal Feed Animals Caloric Restriction* Culture Media Dietary Sucrose / pharmacology Drosophila / physiology* Feeding Behavior / physiology* Longevity / physiology* Mice Yeasts |
| Chemical | |
Reg. No./Substance:
|
0/Culture Media; 0/Dietary Sucrose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Hypercholesterolemia and 3-hydroxy 3-methylglutaryl Coenzyme A reductase regulation in aged female r...
Next Document: PU/PTFE-stimulated monocyte-derived soluble factors induced inflammatory activation in endothelial c...