| Food and pharmaceuticals. Lessons learned from global contaminations with melamine/cyanuric acid and diethylene glycol. | |
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MedLine Citation:
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PMID: 20080484 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recently, contamination of pharmaceuticals with diethylene glycol (DEG) and food with melamine and cyanuric acid has demonstrated the impact of globalization on drug and food safety. By examining the details of these outbreaks, some important lessons can be learned. Toxicoses from contaminated food and drugs are often identified only when large numbers of people or animals are affected and numerous deaths result. Populations most at risk are those repeatedly exposed to a single product. Toxicoses may be complex, involving synergism among relatively nontoxic co-contaminants. Although some contamination may occur inadvertently, practices of deliberate contamination of food and drug ingredients may be widespread but escape detection in poorly regulated markets. If this deliberate contamination is motivated by personal financial gain, it is likely to recur and be concealed. The contaminated raw material produced in a poorly regulated market may cross national boundaries and be used in manufacturing processes for numerous products, sometimes in more well-regulated markets. Once in the production chain, contaminated raw materials may be widely disseminated. It is not clear that regulatory organizations have the capacity to identify significant contaminations despite their best efforts. The veterinary and medical communities, in cooperation with regulatory agencies, should develop cooperative programs designed to detect and limit these global outbreaks. Although addressing regional or national outbreaks remains an important role for regulatory agencies, the veterinary and medical communities must develop proactive global approaches to this global problem. |
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Authors:
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C A Brown; S A Brown |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Veterinary pathology Volume: 47 ISSN: 1544-2217 ISO Abbreviation: Vet. Pathol. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-18 Completed Date: 2010-03-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0312020 Medline TA: Vet Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 45-52 Citation Subset: IM |
Affiliation:
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College of Veterinary Medicine, University of Georgia, 501 D.W. Brooks Drive, Athens, GA 30602, USA. cathybro@uga.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animal Feed
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poisoning Animals Cats Child China Disease Outbreaks / prevention & control, veterinary Dogs Drug Contamination* / prevention & control Ethylene Glycols / poisoning* Food Contamination* / prevention & control Food Handling Food Industry Humans Infant Infant Food / poisoning Kidney / drug effects Triazines / poisoning* World Health |
| Chemical | |
Reg. No./Substance:
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0/Ethylene Glycols; 0/Triazines; 108-78-1/melamine; 108-80-5/cyanuric acid; 111-46-6/diethylene glycol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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