Document Detail

Food intake regulates oleoylethanolamide formation and degradation in the proximal small intestine.
MedLine Citation:
PMID:  17121838     Owner:  NLM     Status:  MEDLINE    
Oleoylethanolamide (OEA) is a lipid mediator that inhibits food intake by activating the nuclear receptor peroxisome proliferator-activated receptor-alpha. In the rodent small intestine OEA levels decrease during food deprivation and increase upon refeeding, suggesting that endogenous OEA may participate in the regulation of satiety. Here we show that feeding stimulates OEA mobilization in the mucosal layer of rat duodenum and jejunum but not in the serosal layer from the same intestinal segments in other sections of the gastrointestinal tract (stomach, ileum, colon) or in a broad series of internal organs and tissues (e.g. liver, brain, heart, plasma). Feeding also increases the levels of other unsaturated fatty acid ethanolamides (FAEs) (e.g. linoleoylethanolamide) without affecting those of saturated FAEs (e.g. palmitoylethanolamide). Feeding-induced OEA mobilization is accompanied by enhanced accumulation of OEA-generating N-acylphosphatidylethanolamines (NAPEs) increased activity and expression of the OEA-synthesizing enzyme NAPE-phospholipase D, and decreased activity and expression of the OEAdegrading enzyme fatty acid amide hydrolase. Immunostaining studies revealed that NAPE-phospholipase D and fatty acid amide hydrolase are expressed in intestinal enterocytes and lamina propria cells. Collectively, these results indicate that nutrient availability controls OEA mobilization in the mucosa of the proximal intestine through a concerted regulation of OEA biosynthesis and degradation.
Jin Fu; Giuseppe Astarita; Silvana Gaetani; Janet Kim; Benjamin F Cravatt; Ken Mackie; Daniele Piomelli
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2006-11-22
Journal Detail:
Title:  The Journal of biological chemistry     Volume:  282     ISSN:  0021-9258     ISO Abbreviation:  J. Biol. Chem.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-08     Completed Date:  2007-03-07     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  2985121R     Medline TA:  J Biol Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1518-28     Citation Subset:  IM    
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MeSH Terms
Amidohydrolases / metabolism
Colon / metabolism
Duodenum / metabolism*
Eating / physiology*
Food Deprivation / physiology
Ileum / metabolism
Intestinal Mucosa / metabolism
Jejunum / metabolism*
Oleic Acids / biosynthesis*,  chemistry,  metabolism*
Phospholipase D / metabolism
Rats, Wistar
Stomach / metabolism
Grant Support
Reg. No./Substance:
0/Oleic Acids; 0/oleoylethanolamide; EC D; EC 3.5.-/Amidohydrolases; EC 3.5.1.-/fatty-acid amide hydrolase

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