| Food intake inhibition by melatonin in goldfish (Carassius auratus). | |
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MedLine Citation:
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PMID: 11336993 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Feeding regulation by monoamines, neuropeptides and certain hormones has been studied in fish, but a possible role of melatonin is unknown. The purpose of the present study was to investigate the effects of melatonin on food intake in goldfish. Fishes were housed in 12L:12D and injected with different doses of either melatonin or 2-iodomelatonin. Two routes of administration, intracerebroventricular and intraperitoneal injections, and two times of the daily photocycle, midday and midnight, were tested. Food intake was measured at 2, 5 and 8 h postinjection. Melatonin and its analog, 2-iodomelatonin intracerebroventricularly injected had no effect on food intake at any time. However, intraperitoneal injections of both indoleamines significantly reduced food intake at different postinjection times. The inhibitory effect of melatonin was blocked by intraperitoneal administration of its antagonist, luzindole. These results demonstrate the in vivo efficiency of luzindole as melatonin antagonist, and thus provide a useful experimental tool to investigate melatonin functions. In conclusion, both melatonin and its agonist 2-iodomelatonin administered peripherally, inhibit food intake in goldfish, and this inhibitory effect appears to be mediated via luzindole-sensitive melatonin receptors. Our results strongly suggest that melatonin is involved in the peripheral satiety mechanisms in goldfish. |
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Authors:
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M L Pinillos; N De Pedro; A L Alonso-Gómez; M Alonso-Bedate; M J Delgado |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Physiology & behavior Volume: 72 ISSN: 0031-9384 ISO Abbreviation: Physiol. Behav. Publication Date: 2001 Apr |
Date Detail:
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Created Date: 2001-05-04 Completed Date: 2001-07-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0151504 Medline TA: Physiol Behav Country: United States |
Other Details:
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Languages: eng Pagination: 629-34 Citation Subset: IM |
Affiliation:
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Departamento de Biología Animal II (Fisiología Animal), Facultad de Biología, Universidad Complutense, 28040, Madrid, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / administration & dosage, pharmacology* Depression, Chemical Eating / drug effects* Goldfish / physiology* Injections, Intraperitoneal Injections, Intraventricular Melatonin / administration & dosage, analogs & derivatives, pharmacology* Tryptamines / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Tryptamines; 117946-91-5/luzindole; 73-31-4/Melatonin; 93515-00-5/2-iodomelatonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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