| Food intake in lean and obese mice after peripheral administration of glucagon-like peptide 2. | |
| | |
MedLine Citation:
|
PMID: 22457516 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We investigated the potential anorectic action of peripherally administered glucagon-like peptide 2 (GLP2) in lean and diet-induced obese (DIO) mice. Mice, fasted for 16 h, were injected i.p. with native GLP2 or [Gly2]GLP2, stable analog of GLP2, before or after GLP2 (3-33), a GLP2 receptor (GLP2R) antagonist, or exendin (9-39), a GLP1R antagonist. Food intake was measured at intervals 1, 2, 4, 8, and 24 h postinjection. In addition, we tested in lean mice the influence of [Gly2]GLP2 on gastric emptying and the effects of GLP1 alone or in combination with [Gly2]GLP2 on food intake. [Gly2]GLP2 dose dependently and significantly inhibited food intake in lean and DIO mice. The reduction of food intake occurred in the first hour postinjection and it was sustained until 4 h postinjection in lean mice while it was sustained until 2 h postinjection in DIO mice. GLP2 significantly inhibited food intake in both lean and DIO mice but only in the first hour postinjection. The efficiency of [Gly2]GLP2 or GLP2 in suppressing food intake was significantly weaker in DIO mice compared with lean animals. The [Gly2]GLP2 anorectic actions were blocked by the GLP2R antagonist GLP2 (3-33) or by the GLP1R antagonist exendin (9-39). The coadministration of [Gly2]GLP2 and GLP1 did not cause additive effects. [Gly2]GLP2 decreased the gastric emptying rate. Results suggest that GLP2 can reduce food intake in mice in the short term, likely acting at a peripheral level. DIO mice are less sensitive to the anorectic effect of the peptide. |
| | |
Authors:
|
Sara Baldassano; Anna Lisa Bellanca; Rosa Serio; Flavia Mulè |
Related Documents
:
|
22652586 - Impact of maternal allergy and use of probiotics during pregnancy on breast milk cytoki... 1889006 - Structure/activity investigations in eight arylalkyltriazenes comparison of chemical st... 1815376 - Qsars for selected aliphatic and aromatic amines. 1378456 - Use of hemo-de to eliminate toxic agents used for concentration and trichrome staining ... 22628186 - C. elegans feeding. 18964586 - Determination of some carbohydrates with n-bromophthalimide and n-bromosaccharin. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-03-28 |
Journal Detail:
|
Title: The Journal of endocrinology Volume: 213 ISSN: 1479-6805 ISO Abbreviation: J. Endocrinol. Publication Date: 2012 Jun |
Date Detail:
|
Created Date: 2012-05-21 Completed Date: 2012-08-09 Revised Date: 2013-03-19 |
Medline Journal Info:
|
Nlm Unique ID: 0375363 Medline TA: J Endocrinol Country: England |
Other Details:
|
Languages: eng Pagination: 277-84 Citation Subset: IM |
Affiliation:
|
Laboratorio di Fisiologia Generale, Dipartimento di Scienze e Tecnologie Molecolari e Biomolecolari (STEMBIO), Università di Palermo, Viale delle Scienze, 90128 Palermo, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Appetite Depressants / pharmacology Diet, High-Fat / adverse effects Dose-Response Relationship, Drug Eating / drug effects* Gastric Emptying / drug effects Glucagon-Like Peptide 1 / pharmacology Glucagon-Like Peptide 2 / pharmacology* Male Mice Mice, Inbred C57BL Obesity / etiology, physiopathology* Peptide Fragments / pharmacology* Receptor Cross-Talk / drug effects Receptors, Glucagon / antagonists & inhibitors, physiology Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Appetite Depressants; 0/GLP-2 receptor; 0/Glucagon-Like Peptide 2; 0/Peptide Fragments; 0/Receptors, Glucagon; 0/glucagon-like peptide-1 receptor; 133514-43-9/exendin (9-39); 89750-14-1/Glucagon-Like Peptide 1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: GluR?2 Assembles Four Neurexins into Trans-Synaptic Triad to Trigger Synapse Formation.
Next Document: Role of ?-adrenergic receptors in regulation of hepatic fat accumulation during aging.