Document Detail


Food intake in lean and obese mice after peripheral administration of glucagon-like peptide 2.
MedLine Citation:
PMID:  22457516     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated the potential anorectic action of peripherally administered glucagon-like peptide 2 (GLP2) in lean and diet-induced obese (DIO) mice. Mice, fasted for 16 h, were injected i.p. with native GLP2 or [Gly2]GLP2, stable analog of GLP2, before or after GLP2 (3-33), a GLP2 receptor (GLP2R) antagonist, or exendin (9-39), a GLP1R antagonist. Food intake was measured at intervals 1, 2, 4, 8, and 24 h postinjection. In addition, we tested in lean mice the influence of [Gly2]GLP2 on gastric emptying and the effects of GLP1 alone or in combination with [Gly2]GLP2 on food intake. [Gly2]GLP2 dose dependently and significantly inhibited food intake in lean and DIO mice. The reduction of food intake occurred in the first hour postinjection and it was sustained until 4 h postinjection in lean mice while it was sustained until 2 h postinjection in DIO mice. GLP2 significantly inhibited food intake in both lean and DIO mice but only in the first hour postinjection. The efficiency of [Gly2]GLP2 or GLP2 in suppressing food intake was significantly weaker in DIO mice compared with lean animals. The [Gly2]GLP2 anorectic actions were blocked by the GLP2R antagonist GLP2 (3-33) or by the GLP1R antagonist exendin (9-39). The coadministration of [Gly2]GLP2 and GLP1 did not cause additive effects. [Gly2]GLP2 decreased the gastric emptying rate. Results suggest that GLP2 can reduce food intake in mice in the short term, likely acting at a peripheral level. DIO mice are less sensitive to the anorectic effect of the peptide.
Authors:
Sara Baldassano; Anna Lisa Bellanca; Rosa Serio; Flavia Mulè
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-03-28
Journal Detail:
Title:  The Journal of endocrinology     Volume:  213     ISSN:  1479-6805     ISO Abbreviation:  J. Endocrinol.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-21     Completed Date:  2012-08-09     Revised Date:  2013-03-19    
Medline Journal Info:
Nlm Unique ID:  0375363     Medline TA:  J Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  277-84     Citation Subset:  IM    
Affiliation:
Laboratorio di Fisiologia Generale, Dipartimento di Scienze e Tecnologie Molecolari e Biomolecolari (STEMBIO), Università di Palermo, Viale delle Scienze, 90128 Palermo, Italy.
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MeSH Terms
Descriptor/Qualifier:
Animals
Appetite Depressants / pharmacology
Diet, High-Fat / adverse effects
Dose-Response Relationship, Drug
Eating / drug effects*
Gastric Emptying / drug effects
Glucagon-Like Peptide 1 / pharmacology
Glucagon-Like Peptide 2 / pharmacology*
Male
Mice
Mice, Inbred C57BL
Obesity / etiology,  physiopathology*
Peptide Fragments / pharmacology*
Receptor Cross-Talk / drug effects
Receptors, Glucagon / antagonists & inhibitors,  physiology
Time Factors
Chemical
Reg. No./Substance:
0/Appetite Depressants; 0/GLP-2 receptor; 0/Glucagon-Like Peptide 2; 0/Peptide Fragments; 0/Receptors, Glucagon; 0/glucagon-like peptide-1 receptor; 133514-43-9/exendin (9-39); 89750-14-1/Glucagon-Like Peptide 1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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