Document Detail

Food intake in laboratory rats provided standard and fenbendazole-supplemented diets.
MedLine Citation:
PMID:  19049253     Owner:  NLM     Status:  MEDLINE    
The benzimidazole anthelmintic fenbendazole (FBZ) is a common and effective treatment for pinworm infestation in laboratory animal colonies. Although many investigators have examined the potential for deleterious biologic effects of FBZ, more subtle aspects of the treatment remain untested. Accordingly, we evaluated differences in food intake when healthy male Sprague-Dawley rats were provided a standard nonmedicated laboratory rodent chow or the same chow supplemented with FBZ. We also tested for a preference for either food type when subjects were provided a choice of the 2 diets. Data from these experiments showed no differences in food intake or body weight when rats were maintained on either standard or FBZ-supplemented chow. When the rats were given access to both the standard and FBZ-supplemented diets, they showed a clear preference for the standard diet. The preference for the standard diet indicates that the rats can discriminate between the 2 foods and may avoid the FBZ-supplemented chow when possible. Investigators conducting experiments during treatment with FBZ in which differences in food preference are relevant should be aware of these data and plan their studies accordingly.
Peter J Vento; Megan E Swartz; Lisa Be Martin; Derek Daniels
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of the American Association for Laboratory Animal Science : JAALAS     Volume:  47     ISSN:  1559-6109     ISO Abbreviation:  J. Am. Assoc. Lab. Anim. Sci.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-12-03     Completed Date:  2009-01-21     Revised Date:  2013-06-04    
Medline Journal Info:
Nlm Unique ID:  101269489     Medline TA:  J Am Assoc Lab Anim Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  46-50     Citation Subset:  IM    
Behavioral Neuroscience Program, Department of Psychology, The State University of New York at Buffalo, Buffalo, NY, USA.
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MeSH Terms
Animals, Laboratory*
Antinematodal Agents / administration & dosage*
Eating / drug effects*
Fenbendazole / administration & dosage*
Food Preferences
Rats, Sprague-Dawley
Grant Support
Reg. No./Substance:
0/Antinematodal Agents; 43210-67-9/Fenbendazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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