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Food intake and energy expenditure are increased in high fat-sensitive but not in high carbohydrate-sensitive obesity prone rats.
MedLine Citation:
PMID:  24898839     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Obesity prone (OP) rodents are used as models of human obesity predisposition. The goal of the present study was to identify pre-existing defects in energy expenditure components in OP rats. Two studies were performed. In the first one, male Wistar rats (n=48) were fed a high-carbohydrate diet (HCD) for 3 weeks then a high-fat diet (HFD) for the next 3 weeks. This study showed that adiposity gain under HCD was 2.9-fold larger in CS than in CR rats, confirming the concept of "carbohydrate sensitive" (CS) rats. Energy expenditure (EE), respiratory quotient (RQ), caloric intake (CI) and locomotor activity measured during HFD identified no differences in EE and RQ between FR and FS rats, and indicated that obesity developed in FS rats only as the result of a larger CI not fully compensated by a parallel increase in EE. A specific pattern of spontaneous activity, characterized by reduced activity burst intensity, was identified in FS rats but not in CS ones. This mirrors a previous observation that under HCD, CS but not FS rats exhibited bursts of activity of reduced intensity. In a second study, rats were fed a HFD for 3 weeks and the components of energy expenditure were examined by indirect calorimetry in 10 FR and 10 FS rats. This study confirmed that a low basal EE, reduced thermic effect of feeding, defective post-prandial energy partitioning or a defective substrate utilization by the working muscle are not involved in the FS phenotype.
Authors:
Dalila Azzout-Marniche; Catherine Chaumontet; Nachiket A Nadkarni; Julien Piedcoq; Gilles Fromentin; Daniel Tome; Patrick C Even
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-4
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  -     ISSN:  1522-1490     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014, American Journal of Physiology - Regulatory, Integrative and Comparative Physiology.
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