Document Detail

Food intake elicited by central administration of orexins/hypocretins: identification of hypothalamic sites of action.
MedLine Citation:
PMID:  10526145     Owner:  NLM     Status:  MEDLINE    
Orexin A and B, a recently identified pair of neuropeptides, are produced in perikarya located in the lateral and perifornical hypothalamus (LH and PFH). Immunoreactive fibers from these neurons innervate several nuclei in the hypothalamus. Orexin A and orexin B stimulate feeding when administered intracerebroventricularly to rats. To identify the specific sites of orexin action, orexin A and B were microinjected into a number of hypothalamic and extrahypothalamic sites in rats. Orexin A was found to enhance food intake when injected into four hypothalamic sites, the paraventricular nucleus (PVN), the dorsomedial nucleus (DMN), LH and the perifornical area, but was ineffective in the arcuate nucleus (ARC), the ventromedial nucleus (VMN), and the preoptic area (POA) as well as the central nucleus of the amygdala (CeA) and nucleus of the tractus solitarius (NTS). Orexin B was not effective at any site tested. These findings demonstrate that orexin A receptive sites for stimulation of food intake exist primarily in a narrow band of neural tissue within the hypothalamus that is known to be involved in control of energy homeostasis.
M G Dube; S P Kalra; P S Kalra
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  842     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-12-21     Completed Date:  1999-12-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  473-7     Citation Subset:  IM    
Department of Physiology, P.O. Box 100274, University of Florida College of Medicine, Gainesville, FL 32610-0274, USA.
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MeSH Terms
Amygdala / drug effects,  physiology
Arcuate Nucleus / drug effects,  physiology
Brain Mapping*
Carrier Proteins / administration & dosage,  pharmacology*
Cerebral Ventricles / drug effects,  physiology
Feeding Behavior / drug effects,  physiology*
Hypothalamus / drug effects,  physiology*
Injections, Intraventricular
Intracellular Signaling Peptides and Proteins*
Neurons / drug effects,  physiology*
Neuropeptides / administration & dosage,  pharmacology*
Paraventricular Hypothalamic Nucleus / drug effects,  physiology
Preoptic Area / drug effects,  physiology
Rats, Sprague-Dawley
Solitary Nucleus / drug effects,  physiology
Ventromedial Hypothalamic Nucleus / drug effects,  physiology
Grant Support
Reg. No./Substance:
0/Carrier Proteins; 0/Intracellular Signaling Peptides and Proteins; 0/Neuropeptides; 0/orexins

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