Document Detail


Food-induced reduction in bioavailability of atenolol.
MedLine Citation:
PMID:  520399     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The influence of food intake on the bioavailability of the beta-adrenoceptor blocker atenolol was assessed by measurement of its single-dose kinetics in ten healthy volunteers, who took 100 mg both in the fasting state and together with a standardized breakfast. Food intake significantly shortened the time to reach peak concentration (2.7 h vs 1.5 h), but caused a significant reduction in AUC values, the mean decrease being 20%. The elimination half-life was unaffected. Atenolol, which is relatively hydrophilic, is incompletely absorbed in the fasting state, and escapes first-pass metabolism. The present findings indicate that food intake causes further impairment of its absorption, even though the absorption rate may initially be enhanced. This contrasts with previous observations on the more lipophilic beta-adrenoceptor blockers propranolol and metoprolol.
Authors:
A Melander; P Stenberg; H Liedholm; B Scherstén; E Wåhlin-Boll
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  16     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1979 Nov 
Date Detail:
Created Date:  1980-03-27     Completed Date:  1980-03-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  327-30     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Atenolol / blood,  metabolism*
Biological Availability
Female
Food*
Humans
Kinetics
Male
Propanolamines / metabolism*
Time Factors
Chemical
Reg. No./Substance:
0/Propanolamines; 29122-68-7/Atenolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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