| Food-induced alterations of intestinal permeability in children with cow's milk-sensitive enteropathy and atopic dermatitis. | |
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MedLine Citation:
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PMID: 2498497 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intestinal permeability was evaluated by measuring the excretion of two orally absorbed (0.1 g/kg of weight) nonmetabolizable markers, mannitol and lactulose. In 39 controls, the lactulose/mannitol urinary ratio (L/M ratio) was 2.45 +/- 1.01% during fasting and remained stable after food ingestion. In 12 children with cow's milk-sensitive enteropathy under an exclusion diet, the L/M ratio was comparable with that of controls during fasting and exhibited a threefold rise during a provocation intestinal permeability test (IPT) with milk. In 28 children with atopic dermatitis (AD), the fasting IPT L/M ratio was significantly higher than in controls (3.60 +/- 3.31%). This rise was related to an increase of lactulose urinary clearance. A provocation IPT with food induced significant L/M ratio changes only in the group in which the food was proved to be responsible for the exacerbation of skin lesions. We concluded that in cow's milk-sensitive enteropathy, an IPT allows a good evaluation of mucosal reactivity to milk, and in AD, permeability changes are present in at least some cases with cutaneous lesions clearly related to food ingestion. |
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Authors:
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C Dupont; E Barau; P Molkhou; F Raynaud; J P Barbet; L Dehennin |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of pediatric gastroenterology and nutrition Volume: 8 ISSN: 0277-2116 ISO Abbreviation: J. Pediatr. Gastroenterol. Nutr. Publication Date: 1989 May |
Date Detail:
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Created Date: 1989-06-26 Completed Date: 1989-06-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8211545 Medline TA: J Pediatr Gastroenterol Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 459-65 Citation Subset: IM |
Affiliation:
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Hôpital St. Vincent de Paul, Paris, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Animals Child Child, Preschool Dermatitis, Atopic / complications* Female Food Hypersensitivity / metabolism* Humans Infant Intestinal Diseases / metabolism* Intestinal Mucosa / metabolism* Lactulose / metabolism Male Mannitol / metabolism Milk / adverse effects* Permeability Radioallergosorbent Test |
| Chemical | |
Reg. No./Substance:
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4618-18-2/Lactulose; 69-65-8/Mannitol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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