Document Detail

Food-induced alterations of intestinal permeability in children with cow's milk-sensitive enteropathy and atopic dermatitis.
MedLine Citation:
PMID:  2498497     Owner:  NLM     Status:  MEDLINE    
Intestinal permeability was evaluated by measuring the excretion of two orally absorbed (0.1 g/kg of weight) nonmetabolizable markers, mannitol and lactulose. In 39 controls, the lactulose/mannitol urinary ratio (L/M ratio) was 2.45 +/- 1.01% during fasting and remained stable after food ingestion. In 12 children with cow's milk-sensitive enteropathy under an exclusion diet, the L/M ratio was comparable with that of controls during fasting and exhibited a threefold rise during a provocation intestinal permeability test (IPT) with milk. In 28 children with atopic dermatitis (AD), the fasting IPT L/M ratio was significantly higher than in controls (3.60 +/- 3.31%). This rise was related to an increase of lactulose urinary clearance. A provocation IPT with food induced significant L/M ratio changes only in the group in which the food was proved to be responsible for the exacerbation of skin lesions. We concluded that in cow's milk-sensitive enteropathy, an IPT allows a good evaluation of mucosal reactivity to milk, and in AD, permeability changes are present in at least some cases with cutaneous lesions clearly related to food ingestion.
C Dupont; E Barau; P Molkhou; F Raynaud; J P Barbet; L Dehennin
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  8     ISSN:  0277-2116     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  1989 May 
Date Detail:
Created Date:  1989-06-26     Completed Date:  1989-06-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  459-65     Citation Subset:  IM    
Hôpital St. Vincent de Paul, Paris, France.
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MeSH Terms
Child, Preschool
Dermatitis, Atopic / complications*
Food Hypersensitivity / metabolism*
Intestinal Diseases / metabolism*
Intestinal Mucosa / metabolism*
Lactulose / metabolism
Mannitol / metabolism
Milk / adverse effects*
Radioallergosorbent Test
Reg. No./Substance:
4618-18-2/Lactulose; 69-65-8/Mannitol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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