| Food hypersensitivity as a cause of rectal bleeding in adults. | |
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MedLine Citation:
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PMID: 19124116 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND & AIMS: Rectal bleeding and lymphonodular hyperplasia (LNH) in children can be caused by food hypersensitivity (FH). Our aim was to verify whether similar clinical and endoscopy presentations in adults can be due to FH. METHODS: Consecutive adult patients with rectal bleeding were enrolled. All underwent routine assays, colonoscopy, and histology study. RESULTS: Ten of 64 (15%) patients showed LNH as the unique sign at colonoscopy. An oligoantigenic diet resolved the rectal bleeding in 9 patients, and the reintroduction of several foods caused symptom reappearance. Double-blind placebo-controlled challenges with cow's milk and wheat protein confirmed the FH; symptoms reappeared 1-96 hours after the challenge. None of the patients were positive for IgE-mediated assays. In patients with LNH and FH, histology of the ileum and colon mucosa showed a higher number of lymphoid follicles and intraepithelial and lamina propria eosinophils compared with the other patients with rectal bleeding. CONCLUSIONS: Recurrent rectal bleeding can be caused by FH in adult patients. Endoscopic evidence of LNH characterizes these cases. |
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Authors:
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Antonio Carroccio; Giuseppe Iacono; Lidia Di Prima; Alberto Ravelli; Giuseppe Pirrone; Angelo B Cefalù; Ada M Florena; Giovan Battista Rini; Gaetana Di Fede |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-08-05 |
Journal Detail:
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Title: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association Volume: 7 ISSN: 1542-7714 ISO Abbreviation: Clin. Gastroenterol. Hepatol. Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2009-01-06 Completed Date: 2009-01-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101160775 Medline TA: Clin Gastroenterol Hepatol Country: United States |
Other Details:
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Languages: eng Pagination: 120-2 Citation Subset: IM |
Affiliation:
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Internal Medicine, Ospedali Civili Riuniti di Sciacca, University of Palermo, Palermo, Italy. acarroccio@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Child Colonoscopy Double-Blind Method Food Hypersensitivity / complications* Hemorrhage / etiology* Histocytochemistry Humans Hyperplasia Immunoglobulin E / analysis Intestinal Mucosa / immunology, pathology Lymph Nodes / pathology Middle Aged Milk Hypersensitivity / diagnosis Placebos / administration & dosage Rectal Diseases / etiology* Recurrence Wheat Hypersensitivity / diagnosis |
| Chemical | |
Reg. No./Substance:
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0/Placebos; 37341-29-0/Immunoglobulin E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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