Document Detail


Food-grade gene expression in lactic acid bacteria.
MedLine Citation:
PMID:  21858927     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In the 1990s, significant efforts were invested in the research and development of food-grade expression systems in lactic acid bacteria (LAB). At this time, Lactococcus lactis in particular was demonstrated to be an ideal cell factory for the food-grade production of recombinant proteins. Steady progress has since been made in research on LAB, including Lactococcus, Lactobacillus and Streptococcus, in the areas of recombinant enzyme production, industrial food fermentation, and gene and metabolic pathway regulation. Over the past decade, this work has also led to new approaches on chromosomal integration vectors and host/vector systems. These newly constructed food-grade gene expression systems were designed with specific attention to self-cloning strategies, food-grade selection markers, plasmid replication and chromosomal gene replacements. In this review, we discuss some well-characterized chromosomal integration and food-grade host/vector systems used in LAB, with a special focus on sustainability, stability and overall safety, and give some attractive examples of protein expression that are based on these systems.
Authors:
Clemens Peterbauer; Thomas Maischberger; Dietmar Haltrich
Related Documents :
18419647 - Estimating consumer exposure to pfos and pfoa.
9414467 - Environmental oestrogens--present understanding.
19125287 - Effect of two durations of short-term intermittent hypoxia on ventilatory chemosensitiv...
10803557 - The use of biomarkers to assess the impact of pollution in coastal environments of the ...
3574787 - Technical developments in the provision of school meals.
7898037 - Influence of food enrichment on cage side preference.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-19
Journal Detail:
Title:  Biotechnology journal     Volume:  -     ISSN:  1860-7314     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101265833     Medline TA:  Biotechnol J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
Food Biotechnology Laboratory, BOKU University of Natural Resources and Life Sciences, Vienna, Austria.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Indexing disease progression at study entry with individuals at-risk for Huntington disease.
Next Document:  Dynamic responses of Xenopus retinal ganglion cell axon growth cones to netrin-1 as they innervate t...