Document Detail

Food frequency questionnaires and overnight urines are valid indicators of daidzein and genistein intake in U.S. women relative to multiple 24-h urine samples.
MedLine Citation:
PMID:  18791925     Owner:  NLM     Status:  MEDLINE    
Data regarding convenient, valid methods for measuring U.S. isoflavone intake are limited. We evaluated a soy food questionnaire (SFQ), the Willett food frequency questionnaire (FFQ), and overnight urine samples relative to excretion in 24-h urine samples. We also described intake among women in a high-risk program for breast or ovarian cancer. Between April 2002 and June 2003, 451 women aged 30 to 50 yr with a family history of breast or ovarian cancer completed the SFQ and FFQ. Of them, 27 provided four 24-h and overnight urine specimens. In these women, 24-h sample measures were correlated with SFQ estimates of daidzein (Spearman r = .48) and genistein (r = .54) intake, moderately correlated with the Willett FFQ (daidzein r = .38, genistein r = .33), and strongly correlated with overnight urine excretion (daidzein r = .84, genistein r = 0.93). Among all 451 SFQ respondents, mean (median) daidzein and genistein intakes were 2.8 (0.24) and 3.9 (0.30) mg/day. Primary sources of both were soymilk, soy nuts, and tofu. We conclude that targeted soy food questionnaires, comprehensive FFQs, and multiple overnight urines are all reasonable options for assessing isoflavone intake in epidemiologic studies.
Marilyn Tseng; Temitope Olufade; Mindy S Kurzer; Kristiina Wahala; Carolyn Y Fang; Yvonne T van der Schouw; Mary B Daly
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nutrition and cancer     Volume:  60     ISSN:  1532-7914     ISO Abbreviation:  Nutr Cancer     Publication Date:  2008  
Date Detail:
Created Date:  2008-09-15     Completed Date:  2009-02-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905040     Medline TA:  Nutr Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  619-26     Citation Subset:  IM    
Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19130, USA.
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MeSH Terms
Biological Markers / urine
Circadian Rhythm
Diet Records*
Genistein / administration & dosage*,  urine*
Isoflavones / administration & dosage*,  urine*
Middle Aged
Phytoestrogens / administration & dosage,  urine
Questionnaires / standards*
Reproducibility of Results
Soy Foods
United States
Grant Support
Reg. No./Substance:
0/Biological Markers; 0/Isoflavones; 0/Phytoestrogens; 446-72-0/Genistein; 486-66-8/daidzein

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