Document Detail


Food-entrained rhythmic expression of apolipoprotein E expression in the hypothalamus of rats.
MedLine Citation:
PMID:  19362542     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Apolipoprotein E (apoE) is a protein mainly synthesized in the liver and brain. To further understand the role of brain apoE in the management of daily food intake, we have examined the circadian pattern of hypothalamic apoE gene and protein expression in freely-fed (FF) and food-restricted (RF, food provided 4 h daily between 1000 h and 1400 h) rats sacrificed at 3-h intervals throughout the light-dark cycle. In FF rats, hypothalamic apoE mRNA and protein levels fluctuated with peaks occuring during the dark phase and the nadirs occuring during the light phase. This pattern was altered in RF rats, which had a marked increase in hypothalamic apoE mRNA and protein levels during the 4-h feeding period in the light phase. Although corticosterone (CORT) levels temporally coincided with the increasing phase of apoE in the hypothalamus in both FF and RF rats, depletion of CORT by adrenalectomy (ADX) did not significantly influence the hypothalamic apoE levels during either period, implying that the circadian pattern of hypothalamic apoE is regulated by factors other than circulating CORT. The finding that hypothalamic apoE and food intake are positively associated during the normal circadian cycle as well as in the period of restricted feeding suggests that hypothalamic apoE is food-entrained and likely involved in the physiological regulation of daily food intake.
Authors:
Ling Shen; Katherine Carey; David Q-H Wang; Stephen C Woods; Min Liu
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-04-09
Journal Detail:
Title:  Brain research     Volume:  1273     ISSN:  1872-6240     ISO Abbreviation:  Brain Res.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-26     Completed Date:  2009-08-14     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  66-71     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adrenalectomy
Animals
Apolipoproteins E / genetics,  metabolism*
Appetite Regulation / genetics*
Circadian Rhythm / genetics*
Corticosterone / metabolism
Darkness
Food Deprivation / physiology
Gene Expression Regulation / physiology*
Hypothalamus / metabolism*
Light
Male
Periodicity
RNA, Messenger / analysis,  metabolism
Rats
Rats, Sprague-Dawley
Grant Support
ID/Acronym/Agency:
DK067550/DK/NIDDK NIH HHS; DK63907/DK/NIDDK NIH HHS; DK70992/DK/NIDDK NIH HHS; R01 DK063907/DK/NIDDK NIH HHS; R01 DK063907-04/DK/NIDDK NIH HHS; R01 DK063907-05/DK/NIDDK NIH HHS; R01 DK067550/DK/NIDDK NIH HHS; R01 DK067550-02/DK/NIDDK NIH HHS; R01 DK067550-03/DK/NIDDK NIH HHS; R01 DK070992/DK/NIDDK NIH HHS; R01 DK070992-01A2/DK/NIDDK NIH HHS; R01 DK070992-02/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Apolipoproteins E; 0/RNA, Messenger; W980KJ009P/Corticosterone
Comments/Corrections

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