| Food deprivation promotes oxidative imbalance in rat brain. | |
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MedLine Citation:
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PMID: 19200099 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study was aimed to evaluate the effect of food deprivation in brain oxidative status of Wistar and Goto-Kakizaki (GK) rats. For this purpose, we evaluated several oxidative stress parameters: lipid peroxidation (thiobarbituric acid reactive substances [TBARS]) and protein oxidation markers, hydrogen peroxide (H(2)O(2)) levels, nonenzymatic (reduced [GSH] and oxidized glutathione [GSSG] and vitamin E) and enzymatic (glutathione peroxidase [GPx], glutathione reductase [GRed], and manganese superoxide dismutase [MnSOD]) antioxidant defenses. Four-mo-old Wistar and GK rats were divided into 2 groups. One group of each rat strain was maintained under normal diet and the other groups were maintained under 50% food deprivation during 2 mo. GK rats under normal diet presented lower levels of vitamin E and higher GRed activity and GSH/GSSG ratio when compared with Wistar control rats. In Wistar rats, food deprivation induced a significant decrease in vitamin E levels and a significant increase in GPx activity, H(2)O(2) production, and TBARS formation in the presence of the prooxidant pair ADP/Fe(2+). However, GK rats under food deprivation presented a significant decrease in vitamin E levels and GRed activity and a significant increase in H(2)O(2) production when compared with GK under normal diet. In summary, our results indicate that food deprivation affects brain oxidative status, which could predispose brain cells to degeneration and death. |
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Authors:
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R X Santos; S Cardoso; S Silva; S Correia; C Carvalho; J Cris?stomo; L Rodrigues; C Amaral; T Louro; P Matafome; M S Santos; T Proen?a; A I Duarte; R Sei?a; P I Moreira |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of food science Volume: 74 ISSN: 1750-3841 ISO Abbreviation: J. Food Sci. Publication Date: 2009 Jan-Feb |
Date Detail:
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Created Date: 2009-02-09 Completed Date: 2009-05-18 Revised Date: 2010-05-24 |
Medline Journal Info:
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Nlm Unique ID: 0014052 Medline TA: J Food Sci Country: United States |
Other Details:
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Languages: eng Pagination: H8-H14 Citation Subset: IM |
Affiliation:
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Dept. of Zoology, Coimbra Univ. Hospital, Univ. of Coimbra, Portugal. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / metabolism* Diabetes Mellitus, Experimental / metabolism Food Deprivation* Glutathione / metabolism* Glutathione Disulfide / metabolism Glutathione Peroxidase / metabolism Glutathione Reductase / metabolism Hydrogen Peroxide / metabolism* Lipid Peroxidation Male Oxidation-Reduction Oxidative Stress* Rats Rats, Wistar Superoxide Dismutase / metabolism Thiobarbituric Acid Reactive Substances / analysis Vitamin E / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Thiobarbituric Acid Reactive Substances; 1406-18-4/Vitamin E; 27025-41-8/Glutathione Disulfide; 70-18-8/Glutathione; 7722-84-1/Hydrogen Peroxide; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase; EC 1.8.1.7/Glutathione Reductase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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