Document Detail

Food deprivation promotes oxidative imbalance in rat brain.
MedLine Citation:
PMID:  19200099     Owner:  NLM     Status:  MEDLINE    
The present study was aimed to evaluate the effect of food deprivation in brain oxidative status of Wistar and Goto-Kakizaki (GK) rats. For this purpose, we evaluated several oxidative stress parameters: lipid peroxidation (thiobarbituric acid reactive substances [TBARS]) and protein oxidation markers, hydrogen peroxide (H(2)O(2)) levels, nonenzymatic (reduced [GSH] and oxidized glutathione [GSSG] and vitamin E) and enzymatic (glutathione peroxidase [GPx], glutathione reductase [GRed], and manganese superoxide dismutase [MnSOD]) antioxidant defenses. Four-mo-old Wistar and GK rats were divided into 2 groups. One group of each rat strain was maintained under normal diet and the other groups were maintained under 50% food deprivation during 2 mo. GK rats under normal diet presented lower levels of vitamin E and higher GRed activity and GSH/GSSG ratio when compared with Wistar control rats. In Wistar rats, food deprivation induced a significant decrease in vitamin E levels and a significant increase in GPx activity, H(2)O(2) production, and TBARS formation in the presence of the prooxidant pair ADP/Fe(2+). However, GK rats under food deprivation presented a significant decrease in vitamin E levels and GRed activity and a significant increase in H(2)O(2) production when compared with GK under normal diet. In summary, our results indicate that food deprivation affects brain oxidative status, which could predispose brain cells to degeneration and death.
R X Santos; S Cardoso; S Silva; S Correia; C Carvalho; J Cris?stomo; L Rodrigues; C Amaral; T Louro; P Matafome; M S Santos; T Proen?a; A I Duarte; R Sei?a; P I Moreira
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of food science     Volume:  74     ISSN:  1750-3841     ISO Abbreviation:  J. Food Sci.     Publication Date:    2009 Jan-Feb
Date Detail:
Created Date:  2009-02-09     Completed Date:  2009-05-18     Revised Date:  2010-05-24    
Medline Journal Info:
Nlm Unique ID:  0014052     Medline TA:  J Food Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H8-H14     Citation Subset:  IM    
Dept. of Zoology, Coimbra Univ. Hospital, Univ. of Coimbra, Portugal.
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MeSH Terms
Brain / metabolism*
Diabetes Mellitus, Experimental / metabolism
Food Deprivation*
Glutathione / metabolism*
Glutathione Disulfide / metabolism
Glutathione Peroxidase / metabolism
Glutathione Reductase / metabolism
Hydrogen Peroxide / metabolism*
Lipid Peroxidation
Oxidative Stress*
Rats, Wistar
Superoxide Dismutase / metabolism
Thiobarbituric Acid Reactive Substances / analysis
Vitamin E / metabolism*
Reg. No./Substance:
0/Thiobarbituric Acid Reactive Substances; 1406-18-4/Vitamin E; 27025-41-8/Glutathione Disulfide; 70-18-8/Glutathione; 7722-84-1/Hydrogen Peroxide; EC Peroxidase; EC Dismutase; EC Reductase

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