Document Detail


Food deprivation promotes oxidative imbalance in rat brain.
MedLine Citation:
PMID:  19200099     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study was aimed to evaluate the effect of food deprivation in brain oxidative status of Wistar and Goto-Kakizaki (GK) rats. For this purpose, we evaluated several oxidative stress parameters: lipid peroxidation (thiobarbituric acid reactive substances [TBARS]) and protein oxidation markers, hydrogen peroxide (H(2)O(2)) levels, nonenzymatic (reduced [GSH] and oxidized glutathione [GSSG] and vitamin E) and enzymatic (glutathione peroxidase [GPx], glutathione reductase [GRed], and manganese superoxide dismutase [MnSOD]) antioxidant defenses. Four-mo-old Wistar and GK rats were divided into 2 groups. One group of each rat strain was maintained under normal diet and the other groups were maintained under 50% food deprivation during 2 mo. GK rats under normal diet presented lower levels of vitamin E and higher GRed activity and GSH/GSSG ratio when compared with Wistar control rats. In Wistar rats, food deprivation induced a significant decrease in vitamin E levels and a significant increase in GPx activity, H(2)O(2) production, and TBARS formation in the presence of the prooxidant pair ADP/Fe(2+). However, GK rats under food deprivation presented a significant decrease in vitamin E levels and GRed activity and a significant increase in H(2)O(2) production when compared with GK under normal diet. In summary, our results indicate that food deprivation affects brain oxidative status, which could predispose brain cells to degeneration and death.
Authors:
R X Santos; S Cardoso; S Silva; S Correia; C Carvalho; J Cris?stomo; L Rodrigues; C Amaral; T Louro; P Matafome; M S Santos; T Proen?a; A I Duarte; R Sei?a; P I Moreira
Related Documents :
16478679 - Intestinal levels of anandamide and oleoylethanolamide in food-deprived rats are regula...
17826779 - Mtii attenuates ghrelin- and food deprivation-induced increases in food hoarding and fo...
6129699 - The opioid peptide dynorphin, circadian rhythms, and starvation.
3945239 - Effect of food and water deprivation on the parameters of the mouse bone marrow micronu...
16055859 - Melatonin and nocturnal migration.
1148859 - Medial and lateral hypothalamic oxygen consumption as a function of age, starvation and...
16546879 - The intake of intense sweeteners - an update review.
18263739 - Inhibition of species of the aspergillus section nigri and ochratoxin a production in g...
18795339 - Fungal associates of pyrola rotundifolia, a mixotrophic ericaceae, from two estonian bo...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of food science     Volume:  74     ISSN:  1750-3841     ISO Abbreviation:  J. Food Sci.     Publication Date:    2009 Jan-Feb
Date Detail:
Created Date:  2009-02-09     Completed Date:  2009-05-18     Revised Date:  2010-05-24    
Medline Journal Info:
Nlm Unique ID:  0014052     Medline TA:  J Food Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H8-H14     Citation Subset:  IM    
Affiliation:
Dept. of Zoology, Coimbra Univ. Hospital, Univ. of Coimbra, Portugal.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Brain / metabolism*
Diabetes Mellitus, Experimental / metabolism
Food Deprivation*
Glutathione / metabolism*
Glutathione Disulfide / metabolism
Glutathione Peroxidase / metabolism
Glutathione Reductase / metabolism
Hydrogen Peroxide / metabolism*
Lipid Peroxidation
Male
Oxidation-Reduction
Oxidative Stress*
Rats
Rats, Wistar
Superoxide Dismutase / metabolism
Thiobarbituric Acid Reactive Substances / analysis
Vitamin E / metabolism*
Chemical
Reg. No./Substance:
0/Thiobarbituric Acid Reactive Substances; 1406-18-4/Vitamin E; 27025-41-8/Glutathione Disulfide; 70-18-8/Glutathione; 7722-84-1/Hydrogen Peroxide; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase; EC 1.8.1.7/Glutathione Reductase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Viscous food matrix influences absorption and excretion but not metabolism of blackcurrant anthocyan...
Next Document:  Depuration of striped venus clam (Chamelea gallina L.): effects on microorganisms, sand content, and...