Document Detail

Food deprivation decreases the blood TRH concentration in the rat.
MedLine Citation:
PMID:  2836225     Owner:  NLM     Status:  MEDLINE    
Adult male rats were deprived of food for 1-6 days and the hypothalamo-pituitary axis in these rats was evaluated. Food deprivation caused a progressive decrease in TRH concentration in the peripheral blood with a concomitant reduction in the blood TSH level. No significant change was observed in the hypothalamic, extrahypothalamic or pancreatic TRH concentration between the control and starved groups. Starvation did not cause a significant change in the pituitary TRH receptors or the in vitro responsiveness of TSH to TRH. These data imply that the reduction in the blood TRH level may contribute in part to the decrease in the blood TSH level after food deprivation, but the origin of the blood TRH has remained to be determined.
M Mori; T Michimata; M Yamada; M Yamaguchi; T Iriuchijima; S Kobayashi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental and clinical endocrinology     Volume:  91     ISSN:  0232-7384     ISO Abbreviation:  Exp. Clin. Endocrinol.     Publication Date:  1988 Mar 
Date Detail:
Created Date:  1988-07-14     Completed Date:  1988-07-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8302802     Medline TA:  Exp Clin Endocrinol     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  97-104     Citation Subset:  IM    
First Department of Internal Medicine, Gunma University, School of Medicine, Maebashi/Japan.
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MeSH Terms
Food Deprivation*
Hypothalamus / metabolism
Pancreas / metabolism
Pituitary Gland, Anterior / drug effects,  metabolism
Receptors, Neurotransmitter / metabolism
Receptors, Thyrotropin-Releasing Hormone
Thyrotropin / blood,  metabolism
Thyrotropin-Releasing Hormone / blood*,  metabolism,  pharmacology
Reg. No./Substance:
0/Receptors, Neurotransmitter; 0/Receptors, Thyrotropin-Releasing Hormone; 24305-27-9/Thyrotropin-Releasing Hormone; 9002-71-5/Thyrotropin

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