Document Detail


Food-dependent Cushing's syndrome.
MedLine Citation:
PMID:  19581669     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It has recently been proposed that other hormones than ACTH can control cortisol production in Cushing's syndrome with bilateral adrenal hyperplasia. We present a case of food-dependent Cushing's syndrome. After a positive response of cortisol production during mixed meals, several tests identified glucose-dependent insulinotropic polypeptide (GIP) as the driving hormone responsible for the cortisol overproduction. Identification of aberrant hormone receptor expression is of importance because it may create a possibility for pharmacological treatment.
Authors:
C Messidoro; J W F Elte; M Castro Cabezas; M van Agteren; A Lacroix; W W de Herder
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Netherlands journal of medicine     Volume:  67     ISSN:  1872-9061     ISO Abbreviation:  Neth J Med     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-07-07     Completed Date:  2009-10-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0356133     Medline TA:  Neth J Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  187-90     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Sint Franciscus Gasthuis, Rotterdam, the Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adrenal Glands / pathology*
Cushing Syndrome / drug therapy,  etiology*,  metabolism*
Female
Food / adverse effects*
Gastric Inhibitory Polypeptide / metabolism*
Gastrointestinal Agents / administration & dosage
Humans
Hydrocortisone / blood,  urine
Hyperplasia
Middle Aged
Octreotide / administration & dosage
Treatment Outcome
Chemical
Reg. No./Substance:
0/Gastrointestinal Agents; 50-23-7/Hydrocortisone; 59392-49-3/Gastric Inhibitory Polypeptide; 83150-76-9/Octreotide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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