Document Detail

Food cues and ghrelin recruit the same neuronal circuitry.
MedLine Citation:
PMID:  23069665     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Cues that are associated with the availability of food are known to trigger food anticipatory activity (FAA). This activity is expressed as increased locomotor activity and enables an animal to prepare for maximal utilization of nutritional resources. Although the exact neural network that mediates FAA is still unknown, several studies have revealed that the medial hypothalamus is involved. Interestingly, this area is responsive to the anorexigenic hormone leptin and the orexigenic hormone ghrelin that have been shown to modulate FAA. However, how FAA is regulated by neuronal activity and how leptin and ghrelin modulate this activity is still poorly understood.
OBJECTIVE: We aimed to examine how the total neuronal population and individual neurons in the medial hypothalamus respond to cue-signaled food availability in awake, behaving rats. In addition, ghrelin and leptin were injected to investigate whether these hormones could have a modulatory role in the regulation of FAA.
DESIGN: Using in vivo electrophysiology, neuronal activity was recorded in the medial hypothalamus in freely moving rats kept on a random feeding schedule, in which a light cue signaled upcoming food delivery. Ghrelin and leptin were administered systemically following the behavioral paradigm.
RESULTS: The food-predictive cue induced FAA as well as a significant increase in neural activity on a population level. More importantly, a sub-population of medial hypothalamic neurons displayed highly correlated identical responses to both ghrelin and FAA, suggesting that these neurons are part of the network that regulates FAA.
CONCLUSION: This study reveals a role for ghrelin, but not leptin, signaling within medial hypothalamus in FAA on both a population level and in single cells, identifying a subset of neurons onto which cue information and ghrelin signaling converge, possibly to drive FAA.
G van der Plasse; M Merkestein; M C M Luijendijk; M van der Roest; H G M Westenberg; A B Mulder; R A H Adan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-10-16
Journal Detail:
Title:  International journal of obesity (2005)     Volume:  37     ISSN:  1476-5497     ISO Abbreviation:  Int J Obes (Lond)     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-07-09     Completed Date:  2014-03-26     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  101256108     Medline TA:  Int J Obes (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  1012-9     Citation Subset:  IM    
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MeSH Terms
Anticipation, Psychological / drug effects
Behavior, Animal
Feeding Behavior / drug effects,  physiology*
Ghrelin / metabolism*,  pharmacology
Hypothalamus / metabolism
Intracellular Signaling Peptides and Proteins / metabolism
Leptin / metabolism*,  pharmacology
Motor Activity / drug effects,  physiology*
Neuropeptide Y / metabolism
Rats, Wistar
Reg. No./Substance:
0/Ghrelin; 0/Intracellular Signaling Peptides and Proteins; 0/Leptin; 0/Neuropeptide Y

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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