Document Detail

Food and cancer.
MedLine Citation:
PMID:  12505279     Owner:  NLM     Status:  MEDLINE    
Food is an important factor in determining cancer incidence in many countries and regions. Food components relevant to cancer development can be divided into macro- and microcomponents. The former tends to act indirectly. The latter usually has a clearly defined action, for example as genotoxic agents. Food can have both positive (carcinogenic) and negative (preventive) effects. Total calory intake appears to have a strong positive influence on cancer incidence. Food typical of advanced nations including fat-rich food is associated with increases in breast, colon and prostate cancers. Vegetables rich in antioxidants and fibers tend to reduce cancer incidence. Carcinogenic plant alkaloids, myctoxins and other food contaminants frequently enter our bodies. Heat-cooking generates genotoxicants, including aromatic hydrocarbons (via combustion) and heterocyclic amines (HCAs) through reactions involving creatin(in)e, sugar and amino acids in meat. HCAs are relatively newcomers as food genotoxicants and can produce breast, colon and prostate cancers in rodents. Some epidemiological investigations positively correlate HCA intake and cancer incidence. HCAs can produce other toxicological effects including salivary gland atrophy and myocardial degeneration. Improved food, better life styles and developments in the functional food industry are all crucila to cancer prevention.
Takashi Sugimura
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Toxicology     Volume:  181-182     ISSN:  0300-483X     ISO Abbreviation:  Toxicology     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-12-30     Completed Date:  2003-02-28     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0361055     Medline TA:  Toxicology     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  17-21     Citation Subset:  IM    
National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.
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MeSH Terms
Anticarcinogenic Agents / analysis
Carcinogens / chemistry,  toxicity
Mutagens / chemistry,  toxicity
Neoplasms / epidemiology*,  etiology,  prevention & control
Reg. No./Substance:
0/Anticarcinogenic Agents; 0/Carcinogens; 0/Mutagens

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