| Food-bound B12 absorption and serum total homocysteine in patients with low serum B12 levels. | |
| | |
MedLine Citation:
|
PMID: 9723575 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
This study was undertaken to determine whether measurements of serum total homocysteine (Hcys) and bound B12 absorption are useful in determining which patients with low- or low-normal levels of serum B12 are B12 deficient. In 40 patients with low or borderline serum levels of B12, food-bound B12 absorptions were determined using a body counter in an iron room, and were related to serum total Hcys levels. Food-bound B12 absorption was decreased in 16 patients and in an additional four, absorption of the free vitamin was also decreased. Homocysteine levels were elevated in four of the 16; in three of the four who had both decreased bound and free B12 absorptions, Hcys was elevated. If elevation of the Hcys level indicates tissue deficiency of B12, the 75% incidence of normal levels of Hcys in these patients with low food-bound B12 absorptions suggests the existence of a cohort of patients who may be at risk to develop, but have not yet developed, B12 deficiency. Only long term follow-up will reveal how many ultimately will become B12 deficient. |
| | |
Authors:
|
A Miller; D W Slingerland; C A Hall; R C Chu |
Related Documents
:
|
6841135 - Analytical versus food table values for vitamin c in foods: the effect on calculated vi... 15289425 - Vitamin b12 (cobalamin) deficiency in elderly patients. 19025725 - The association between dietary vitamin k intake and serum undercarboxylated osteocalci... 12151575 - Will an orange a day keep the doctor away? 16332615 - Ochratoxin a: previous risk assessments and issues arising. 18423005 - Mapping the evolution of 'food deserts' in a canadian city: supermarket accessibility i... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: American journal of hematology Volume: 59 ISSN: 0361-8609 ISO Abbreviation: Am. J. Hematol. Publication Date: 1998 Sep |
Date Detail:
|
Created Date: 1998-09-22 Completed Date: 1998-09-22 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 7610369 Medline TA: Am J Hematol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 42-5 Citation Subset: IM |
Affiliation:
|
Medical Service, VAMC, Boston, Massachusetts 02130, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Blood Cell Count Female Folic Acid / blood Food Gastrins / blood Homocysteine / blood* Humans Intestinal Absorption Male Middle Aged Vitamin B 12 / blood, pharmacokinetics* Vitamin B 12 Deficiency / blood* |
| Chemical | |
Reg. No./Substance:
|
0/Gastrins; 454-28-4/Homocysteine; 59-30-3/Folic Acid; 68-19-9/Vitamin B 12 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Viral infections among patients with hemophilia in the state of Georgia.
Next Document: Prothrombin mutant, factor V Leiden, and thermolabile variant of methylenetetrahydrofolate reductase...