Document Detail

Food-borne radiolytic compounds (2-alkylcyclobutanones)may promote experimental colon carcinogenesis.
MedLine Citation:
PMID:  12734067     Owner:  NLM     Status:  MEDLINE    
Food irradiation is acknowledged as a safe process to improve food quality by reducing microbial contamination. Information on the toxicological potential of 2-alkylcyclobutanones (2-ACBs), radiolytic derivatives of triglycerides found exclusively in irradiated food, is scarce. Wistar rats received daily a solution of highly pure 2-tetradecylcyclobutanone (2-tDCB) or 2-(tetradec-5-enyl)-cyclobutanone (2-tDeCB) at a concentration of 0.005% in 1% ethanol as drinking fluid, while control animals received 1% ethanol. All animals received a single intraperitoneal injection of the chemical carcinogen azoxymethane (AOM) at Weeks 3 and 4. At 3 mo after AOM injection, no significant changes were observed in the total number of preneoplastic lesions in the colon of AOM controls and 2-ACB-treated animals. After 6 mo, the total number of tumors in the colon was threefold higher in the 2-ACB-treated animals than in the AOM controls. The colon of four of six AOM control rats exhibited only one small tumor ( &6 mm3). Multiple tumors were observed in four and three of six animals treated with 2-tDCB or 2-tDeCB, respectively. Medium (6 < S < 25 mm3) and larger (>25 mm3) tumors were detected only in 2-ACB-treated animals. This is the first demonstration that a compound found exclusively in irradiated dietary fats may promote colon carcinogenesis in animals treated with a chemical carcinogen.
Francis Raul; Francine Gosse; Henry Delincee; Andrea Hartwig; Eric Marchioni; Michel Miesch; Dalal Werner; Dominique Burnouf
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nutrition and cancer     Volume:  44     ISSN:  0163-5581     ISO Abbreviation:  Nutr Cancer     Publication Date:  2002  
Date Detail:
Created Date:  2003-05-07     Completed Date:  2003-12-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905040     Medline TA:  Nutr Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  189-91     Citation Subset:  IM    
Laboratoire d'Oncologie Nutritionnelle, F-67000 Strasbourg, France.
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MeSH Terms
Analysis of Variance
Azoxymethane / administration & dosage,  adverse effects
Carcinogens / administration & dosage,  adverse effects
Colonic Neoplasms / chemically induced,  etiology*
Cyclobutanes / adverse effects*
Disease Models, Animal
Food Irradiation / adverse effects*
Neoplasms, Experimental / chemically induced
Rats, Wistar
Reg. No./Substance:
0/Carcinogens; 0/Cyclobutanes; 25843-45-2/Azoxymethane

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